57 results
The main objective of this study is to find (epi)genetic markers including SNPs/haplotypes, DNA methylation and RNA expression correlating with cognitive decline in clinical patients with Mild Cognitive Impairment (MCI) and Subjective Cognitive…
To study the longitudinal dynamics of blood biomarkers, including NfL, in patients with frontotemporal dementia.
The present study will examine how young-onset-dementia patients and their families can be supported in their home environment as long as possible and institutionalisation can be delayed. For this the functioning and care needs of young-onset-…
Primary Objective: Our main goal is to contribute to the identification of an attentional profile of the paediatric TBI population, by analysing the quality and efficiency of alerting, orienting, executive and sustained attentional functioning. This…
1) To determine if microinfarcts can be detected in the brain with 7T MRI in AD patients2) To determine the prevalence and number of cerebral microbleeds on 7T MRI in patients with AD and to relate these lesions to cognition and to the vascular risk…
What are the long-term consequences of prenatal exposure to cannabis and nicotine on the brain development of 6-year old children?
The main objective of this study is to characterize the flow of information in the fronto-parietal network during the simulation of movements using intracranial EEG recordings. In the characterization we will pinpoint the neuronal (sub)regions of…
* To implement a standardised MRI acquisition protocol in multiple centres across Europe (Part A).* To identify and evaluate new biomarkers of disease progression in patients with amnestic MCI by collecting biochemical, neuroimaging,…
The primary objective is to evaluate the presence of brain damage (defined by white matter lesions (WMLs) or cerebral atrophy or deviations at neuropsychological examination (NPE)) among adults with tetralogy of Fallot (TOF). The secondary objective…
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
Primary Objective: To examine which subregions of the hippocampal formation on 7 Tesla MRI are most affected in patients with early Alzheimer*s disease compared with older persons with normal cognition. Secondary Objectives:a) To explore risk…
The general objective is to validate and assess the clinical and economic added-value of a) innovative diagnostic tests developed in WP1 (PET tracers), WP2 (ultra high field MRI) and WP3 (CSF), and b) other emerging diagnostic tests for Alzheimer…
The first (primary) objective (study 1) is to examine 1a) risk factors for volume loss in the entorhinal cortex and compare these with risk factors for volume loss in the rest of the hippocampus at 1.5T MRI over 7 years of follow-up; and to examine…
To assess the impact of OH on cerebral perfusion and function in severe OH in AF (n=10) and healthy controls (n=10).
Primary objective: To determine whether the short-term neurological outcome of surviving children diagnosed with prenatally diagnosed ventriculomegaly is associated with the extent of VM before birth.Second objective: To determine whether the…
This pilot is meaned to obtain:- experience and understanding in the presence of new embolic load in the brain by means of DW-MRI- Understanding in the number of patients in which probably the post-operative DW-MRI can not be done according to…
The main question in the study isHow do moderately preterm infants and their parents differ from term, as well as extreme preterm infants in (a) development and self regulation skills of the infants, (b) interaction patterns and relationship between…
ObjectiveTo assess the prevalence of PHD and chronic fatigue in Dutch TBI patients, and to study the relationships between the various aspects of chronic fatigue and PHD, with particular emphasis on the association between chronic fatigue, and…
Objective of the study: The main objective of this study is to investigate the influence of different genetic mechanisms (risk genes, CNVs and gene expression profiles) in ASD and to study the relation between the genetic heterogeneity and specific…
Translation follows at a later stage.