156 results
This study has been transitioned to CTIS with ID 2024-517634-17-01 check the CTIS register for the current data. The main objectives are to 1) investigate the relation between (longitudinal) tau and amyloid accumulation in cognitively normal…
To explore the efficacy of central thalamic DBS in restoring consciousness in MCS patients. Hypothesis: Central thalamic DBS improves the level of consciousness in MCS patients.
We address two primary objectives: 1.) To determine whether (awake) surgery on patients with a brain tumor or epilepsy allows for HD-ECoG data collection of adequate quality to address research questions on brain function. In other words, we want to…
This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.
The primary objective is the evaluation of the potential positive effect of a compensatory memory strategy game on effective coping with memory problems and reducing subjective memory failures in ABI patients with memory deficits in the chronic…
The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on (regional) brain vascular function and insulin-sensitivity, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-…
The BeyeOMARKER study*s primary aim is to (1) evaluate the real-world predictive value of blood- and eye-based biomarkers for detection of AD-related clinical progression and biological changes in eye clinics. Secondly, we aim (2) to assess the…
The current study aims to obtain a better understanding of glymphatic dysfunction in dementia of the Alzheimer*s type and its preclinical stages.The main objective of this study is to improve our understanding of the potential link between…
To examine the cross-cultural acceptability of four interventions in dementia care that typically aim to increase control over the end of life among people with dementia, and family and professional caregivers. Differences in acceptability between…
The precise pathophysiology for hypertension causing brain damage is still unclear, although microvascular dysfunction is thought to play an important role. Therefore, in this study the small cerebral vessels will be studied in more detail. The main…
This study has been transitioned to CTIS with ID 2024-518559-41-01 check the CTIS register for the current data. The main objectives are to identify markers for amyloid pathology in cognitively normal subjects, to identify risk factors for amyloid…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…
(1) investigate alterations in executive functioning in extremely preterm-born adolescents in the Netherlands relative to term-born controls, (2) assess the neurobiological basis of individual variability in executive functioning following preterm…
We aim to assess the association between variability and irregularity in heart rate (as caused by permanent atrial fibrillation), and cognitive function. In addition, variability and irregularity of the peripheral blood pressure will be correlated…
The aim of the study is to be able to estimate the long-term neurological outcomes in patients with acute severe brain injury in the acute phase. This is accomplished through additional neurological clinical studies, EEG reactivity testing, imaging…
This study has been transitioned to CTIS with ID 2023-508363-79-00 check the CTIS register for the current data. Part AMain objectives: • To evaluate the safety and tolerability of single intrathecal (IT) doses of ALN-APP in adult patients with…
The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…
To evaluate the safety and tolerability of ENX-102 following repeated doses in healthy volunteers
This study has been transitioned to CTIS with ID 2024-511610-20-00 check the CTIS register for the current data. Cognitive and functional abilities will be evaluated using psychometric scales (ie, cognitive subscale of the Alzheimer*s Disease…