5297 results
Primary ObjectivesPart A: RO6874281 Dose Escalation as a Single AgentThe primary objectives for this study are as follows:* To describe the safety and tolerability profile of RO6874281 as a single agent* To determine the maximum tolerated dose (MTD…
Examining the longitudinal associations between negative peer experiences on adolescent inflammation
The main objective of this study is twofold: 1) To investigate the additive and interactive effects between negative peer experiences at the group level (i.e., peer victimization, peer rejection) and at the dyadic level (e.g., friendship) on…
Efficacy ObjectivesThe primary efficacy objective for this study is as follows:• To evaluate the efficacy of adjuvant atezolizumab treatment in patients with PD- L1*selected muscle invasive urothelial cancer, as measured by disease-free survival (…
In this study the best treatment of DSPS will be investigated by comparison of existing treatments. We will investigate is patients with ADHD and DSPS have less favorable blood values for biomarkers of chronic diseases in comparison with norm values…
To examine the goals of patients and doctors for treatment with chemotherapy, immunotherapy or targeted therapy in metastatic lung cancer and whether these goals are achieved according to patients, doctors and relatives.
to determine the prevalence of endometriosis in female patients diagnosed with irritable bowel syndrome
- The main objective of this study is to develop a predictive model that can estimate the rest energy expenditure in indviduals with SCI or LLA.- To develop a model based on raw accelerometry data that can estimate the energy expenditure during ADL…
In this study we will identify the role of the endothelial GAGs in Na+ and volume homeostasis. Is there a link between the ESL and individual susceptibility to Na+-excess?
The current study will examine the safety and pharmacokinetic profile of JWH-018.
The primary objective is to assess how training, acutely and chronically, influences gene expression patterns in different individuals.Gene expression values of samples taken around an exercise performance test will be used to assess the acute…
To evaluate the cost-effectiveness of the Demands and Capacities Model based treatment (Dutch standard) compared to the Lidcombe programme for early stuttering intervention.Follow-up: Long-term outcome, taking into account recent genetic findings.
The main objective of the present study is to investigate whether it is possible to use the VOC pattern in exhaled air as a parameter of metabolism of lipids.Primary Objective: To investigate the difference in postprandial change in volatile organic…
To assess, in patients with non-specific low back pain, lasting for over 3 months, the effect of two doses of olpadronate administered intravenously on low back pain as compared to placebo treatment. Assessment of safety and tolerability are also…
The objective of the study is to investigate if predictors of cardiac responsiveness are able to predict a renal response to fluid administration in oliguria.
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…
To assess the anabolic response to plant based protein intake.
To investigate the effect of odor exposure on eating behavior (appetite, intake) in nursing home residents with dementia
To validate and demonstrate reproducibility of the identified sepsis CR gene signature in participants from different age groups. The validation multicenter study will also lead to biomarker refinement of the original core set of 31 genes tailored…
Research on e-liquid flavors could be performed through smelling or tasting (*vaping*) experiments. The main objective of the Smell-e study is to determine if there is a correlation between liking of e-liquid flavors through smelling and liking of e…
The primary objective of this study is to investigate the course of plasma- and urinary levels of different carnitine-esters during IV administration of oxaliplatin.