56 results
The objective of the study is to determine the protein profile of cerebrospinal fluid of non-pregnant women using mass-spectrometry.This study is a follow-up project on the previously performed study (LEPRA, CSF and pre-eclampsia, MEC 2007-087). In…
1a. Determine whether the effect of low-molecular-weight heparin can be explained by aspirin resistance. 1b. Assess the consistency of aspirin resistance during and after pregnancy measured with several complementary devices. 2. Determine…
a. To investigate the phenotype and function of immunological cells present in endometrial and peripheral blood of women with a history of recurrent miscarriages and women without any known pregnancy complications.b. To investigate the association…
In the present proposal, we aim to assess the cost-effectiveness of the use of CGMS in diabetic pregnancies.
The main goal of this study is to establish the reliability (internal consistency and interrater reliability) and validity (discriminant, contruct and predictive validity) of the INCAS. Differences between the SMI and healthy group will be studied (…
The prime objective of the IMPROvED project is to develop a clinically robust predictive blood test for pre-eclampsia, using innovative technologies and utilising novel metabolite and protein biomarkers. This blood test is targeted to all first time…
The principal aim of this study is to elucidate the role of the glycocalyx in the pathogenesis of pre-eclampsia by assessing: - Whether the glycocalyx is affected in pre-eclampsia and is related to its severity.- Whether glycocalyx perturbation is…
To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness and decidual acceptance (the quality of decidualization, endometrium-embryo communication and endometrial stromal cell (ESC) migration) and B) the angiogeneic…
This study aims to test whether non-invasive measures of SNS activity can predict preeclampsia and whether magnesium sulphate in preeclamptic patients reduces the hypersympathetic state. We will quantify SNS activity using the pre-ejection period (…
Applicability of fetal brain imaging techniques for clinical purposes.
What is the most reliable way, defined as the lowest percentage rate of urines which are contaminated, to collect urine in pregnant women to asses bacteriuria? Comparison of three different methods of collection: midstream morning urine, midstream…
Main objective of this pilot study is to compare vascular lesions of the placental bed spiral artery characteristics in pre-eclampsia to spiral artery samples after an uncomplicated pregnancy. Aim of the pilot study will also be to determine the…
To investigate whether SAF is elevated in GDM versus non-diabetic pregnancy To investigate whther SAF levels change during the course of normal and GDM pregnancy To investigate if SAF is related to other parameters of hyperglycemia (HbA1c, self…
The present study has 2 primary objectives: 1: The first aim of the present study is to explore early detection possibilities using plasma hemopexin activity and plasma ATP levels in cohorts of pregnant women in a time course manner (experiment 1).…
Primary Objective: The main objective of this study is to analyse the effects of pregnancy on levels and percentages of CD8 cell subsets in peripheral blood both during and after pregnancy.
We aim to determine an association between the presence of complement binding anti-paternal HLA-C antibodies and preeclampsia.
This study aims to explore the pattern of change in cardiovascular sympathetic activity in response to pregnancy by estimating the central sympathetic activity by measuring the pre-ejection period (PEP). The PEP is considered the golden standard for…
This study will assess the capacity of quantitave fetal fibronectin testing as compared to or in addition of cervical length measurements and vaginal digital exams to predict preterm delivey in women with symptoms of preterm labour.
To evaluate whether cognitive function of formerly preeclamptics is diminished and correlated with dynamic cerebrovascular control properties using non-invasive measuring techniques (dynamic cerebral autoregulation, neurovascular coupling). Question…
Primary objective:• To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful pregnancy.Secondary…