32 results
The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…
To determine whether administration of exogenous surfactant using a minimally-invasive technique improves outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP).
The aim of the trial is to obtain data on the optimal dose, feasibility and pharmacokinetics of bumetanide when given as an add-on treatment for seizures in full term babies with hypoxic ischemic encephalopathy (HIE). Bumetanide will be given in a…
In this multicenter trial we compare resuscitation of preterm neonates with either 5 cm H2O PEEP or 8 cmH2O PEEP. We think resuscitation with 8 cmH2O PEEP results in a better outcome compared to resuscitation with 5 cmH2O PEEP.
Evaluation of the effects of intravenous lipid and extra amino acid supplementation from birth onwards to very low birth weight infants on amino acid turnover and protein accretion. As secondary objectives the safety, energy expenditure and short-…
The development of a disease specific questionnaire to measure the quality of life in children with BPD at age 4-8, that can be answered by the parents.
The objective is to study the effectiveness of the Triple P program compared to a control group, for parents and their NICU-graduates with emotional and/or behavioral problems. Effectivenes concerns children's problems, parents' parenting…
To evaluate the bowel function, quality of life and nutritional status in adolescents/adults who experienced an episode of NEC at neonatal age.
Primary objective: to study the pharmacokinetics and pharmacodynamics of paracetamol intravenously in preterm infants with a gestational age of less than 32 weeks:Secondary objective(s): to study the safety and dose-effect relationship of…
To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…
This project aims to develop an evidence based effective and "safe" dosing regimen for commonly used life saving medicationsused in the treatment of asphyxiated, critically ill newborns, undergoing therapeutic hypothermia.To this aim the…
Study (population) pharmacokinetics of midazolam, morphine, phenobarbital and lidocaïne during therapeutic hypothermia for adequate dose adjustments.
To asses the effect of intermittent bolus nasogastric milk feeding versus semi-continuous milk feeding in preterm infants
This study-protocol is directed at the comparison of two accepted management strategies at both ends of the current treatment-spectrum of moderate hypoglycemia in 'high risk' newborns: an intensive treatment versus an expectant monitoring…
To determine the rate of transmission of prilocaine across the placentaTo determine the levels of methemoglobinemia in newborns after perineal block with prilocaine during labor (following the regimen used in our hospital)To determine the levels of…
To quantify splanchnic and whole body aspartate metabolism in premature neonates.
1. To determine the rate of splanchnic utilization of glutamine, proposed to be conditionally essential for premature infants.2. To quantify the rate of splanchnic oxidation of dietary glutamine, which is supposed to be one of the major fuel…
To investigate whether non-invasive ear magnetic acupuncture will help reduce pain and stress for preterm infants in the Neonatal Intensive Care Unit (NICU) during their routine eye examination for Retinopathy of Prematurity (ROP).
Primary Objective: To assess the agreement between the heart rate assessed with a dedicated cap with integrated PPG-leads and standard ECG monitoring using regular neonatal thoracic electrodes as reference technique.Secondary objectives:Does…
To inform the frequency of women at higher FNAIT risk among pregnant women of different racial and ethnic characteristics who present for pre-natal care and to assess the occurrence of HPA-1a alloimmunization in these women. It is planned that data…