53 results
To collect maternal blood during the 2nd half of pregnany, in combination with clinical data and data on pregnancy outcome.
Our objective is to test the following hypotheses : - Hypothesis 1 (part 1 of the study): The stress reduction intervention has beneficial effects on subjective maternal emotional well-being, on objective maternal stress system measures (i.e., HPA-…
Aim of this study is to identify how pregnancy complications can be predicted from the interplay between psychological, social and somatic risk factors. We hypothesize that the personality trait neuroticism predisposes to complications of pregnancy…
The primary objective of the PRIDE Study is to identify factors to which a woman is exposed during her pregnancy that have an influence on the health status of the mother and/or her (unborn) child. In addition, the evaluation of preconception,…
Primary Objectives: To prospectively investigate the changes in cardiac parameters (echocardiography, NT-pro-BNP) and uteroplacental flow (pulsatility index, diastolic notching) during/after pregnancy in women with CHD and compare these changes with…
to determine the correlation of fetal hyperinsulinemia (measured by urine c-peptide) and maternal indicators of glucose-regulation with neonatal birth weight and postpartum glucose concentration of macrosomic infants of non-diabetic mothers
The relationships between emotional complaints of the mothers during pregnancy and the self regulation capacities, temperament, mental and motor development of the children are studied, taking into account the influence of the father, that could be…
The objective of this study is to test the hypothesis that healthy obese pregnant women at increased risk for obesity-related pregnancy complications can be identified by a subgroup-specific screening program at twelve weeks amenorrhea.
To investigate the association of anatomical defects with the occurrence of stress urinary incontinence.
The primary objective is to examine whether the pain threshold during pregnancy is associated with the intensity of the pain and whether there is difference between before and during pregnancy. In addition, we examine associations between (pro)…
Primary objective:To demonstrate elevated numbers of CEC in clinically symptomatic patients with severe preeclampsia.Secondary objectives:- To analyze the relation of CEC levels with organ damage and dysfunction. - To analyze the relation of CEC…
The general aim of the Generation R Study is to examine environmental and genetic causes that influence growth, development and health during fetal life, childhood and adulthood.The more specific aims of the study are: (1) To describe normal and…
The primary objectives :Are children of mothers with sub-optimal thyroid function and/or sub-clinical hypothyroidism and/or hypothyroxinemia during early pregnancy at risk for developmental delay at the age of two and does this possible delay…
The primary endpoint will be descriptive histology on placental bed biopsies and placenta in healthy pregnant women or women with preeclampsia and/or IUGR in need of caesarean section. In particular, the study will aim to find the degree of…
In this project we hypothesize that recurrent pregnancy miscarriages is an issue stemming from both the female as the male. The overall aim is to elucidate paternal factors associated with RPL (A) and to assess the predictive value of these factors…
Primary Objective:Delineate the differences in cellular composition and function at the maternal-fetal interface in patients with SLE compared to healthy women Secondary Objectives:- Establish a novel in-vitro model to study cell-cell interaction at…
The aim of this study is to determine functional parameters of the maternal heart during the lactation period by echocardiography and to correlate these functional parameters with circulating hormones.
To assess embryonic, foetal and placental growth trajectories by serial assessments of sizes and volumes and foetal morphology during the first, second and third trimester of pregnancy with the aim to examine whether BS influences embryonic growth…
The main objective of the Brabant Study (BS) is to investigate possible different trajectories of thyroid function during pregnancy taking hCG hormone into account. Moreover, we aim to investigate whether pregnancy complications (e.g. pre-eclampsia…
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…