262 results
Identification of protein profile differences between laryngeal cancer of young and elderly patients. Secondary objective is to identify differences between protein interaction network in cancer and healthy tissue in young and elderly laryngeal…
-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
* To define the characteristics of patients with severe asthma in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma, and healthy controls* To repeat the measurement of clinical…
The researchquestion of this study:Is there an association between the respiratory and cardiovascular system in early childhood? If there is an assocation, what are its determinants?
To investigate the presence and extent of small airways disease in subjects with asymptomatic AHR, patients with asthma and non-AHR controls. Specific research questions:1) Do subjects with asymptomatic AHR have less small airways disease than…
Primary Objective: To determine the prevalence of endo- and extranasal deformities, problems with nasal functioning and satisfaction with nasal appearance in patients with TCS.Secondary Objective: To adjust and improve the treatment of patients with…
I. To evaluate what the impact is of posterior scoliosis correction on respiratory muscle function (strength, endurance, power and work of breathing).II. To evaluate the relation of changes in respiratory muscle function, due to the posterior…
To study the effect of early tumour development on brown adipose tissue activity
Main objective: To investigate differential gene-expression in nasal epithelium of asthmatics in complete remission, in clinical remission, not in remission and healthy controls.
Primary objectives of the pilot study• To determine childhood cardiovascular health in offspring of PCOS mothers and to compare it with children from non-PCOS mothers.Secondary objectives of the pilot study• To compare cardiovascular risk factors…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
Primary Objective: To identify new clinical phenotypes in patients with severe chronic obstructive pulmonary disease (COPD) using a cluster analysis.Secondary Objectives: To:- identify clinical phenotypes (based on e.g. lung function parameters,…
Study 1: The purpose of this study is to gain more insight in the characteristics that are related to vascular damage at a young age, and particularly to detect if obesity is related to vascular damage (and thus the risk of cardiovascular disease in…
Is there an association between involvement in incidents with airway irritants and respiratory effects in first responders.
The first aim of the study is to determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls. The second aim is to value…
Development of a new technics to improve the diagnostic value of an EUS procedure in combination with reducing the amount of biopsies.
To examine the influence of genetic predisposition, genetic factors, infections and lifestyle of mother and child in relation to 1) allergic diseases and childhood astma;2) childhood overweight and obesity; 3) cardiopulmonary fitness and…