88 results
Primary objectives:1.1 To investigate the differences between patients* and resident loved ones' perceptions of patients* health status and problematic ADLs.1.2 To study prospectively the effects of an acute COPD exacerbation on resident loved…
The aim of the current study is evaluation of the Certe A/C service system. This is achieved via 2 workpackages:Workpackage 1 constitutes of describing patient characteristics (age, gender, current medication, smoking status and comorbidities) of…
To evaluate long term safety, efficacy and airway remodelling effects of BT in patients with severe asthma.
The objectives are to study short-term changes in lung function, exhaled NO, respiratory symptoms and bronchodilator medication use in association with short-term changes in UFP in general and UFP from aircraft emissions specifically in children…
The main objective of the panel study is to evaluate the associations between short-term variation of concentrations of key air pollutants (NO2, PM2.5, PM10, and ultrafine particles), measured on a fine spatial and temporal resolution, and short-…
The aim of this study is to investigate the relationship between atrial septal defects and airway responsiveness before and after percutaneous closure.
To determine the prevalence of mycobacterial, propionibacterial and beryllium, aluminium and zirconium sensitized patients within a well-defined Dutch cohort of biopsy proven sarcoidosis patients.New clinico-pathological phenotypes within the group…
The purpose of the study is to evaluate the usability of PatientCoach by patients with asthma and/ or COPD,hypertension and/or Diabetes Mellitus.
To determine whether pulmonary rehabilitation prior to bariatric surgery leads to improved and sustained asthma control (ACQ) as compared to bariatric surgery alone in patients with morbid obesity and not optimally controlled asthma.Secondary aims…
Main objective: To investigate differential gene-expression in nasal epithelium of asthmatics in complete remission, in clinical remission, not in remission and healthy controls.
Study 1: The purpose of this study is to gain more insight in the characteristics that are related to vascular damage at a young age, and particularly to detect if obesity is related to vascular damage (and thus the risk of cardiovascular disease in…
The primary research question is:Do children with atopic dermatitis and asthma after a stay in the NAD have a better coping and acceptance of their disease as compared with children treated at the outpatient department of the WKZ?Secondary research…
This study is designed to identify molecular and cellular profiles in peripheral blood, urine, induced sputum, and bronchial tissue from three main categories of asthma (persistent mild, moderate and severe) and to correlate these profiles to…
This study aims to determine the normal distribution of desmosine in a healthy population and a population of patients with COPD (ranging from GOLD I-IV). In addition, the inter-day variation and the correlation with 24-hour urinary desmosine will…
The current proposal studies the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of overweight/obese children with asthma. Also the underlying mechanism of these…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
The aim of this study is to develop a patient reported outcome tool specific to small airways disease, which assesses symptoms and signs of small airways disease and could help in addition to FEF50% to discriminate between asthmatic patients with…
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
We hypothesize that ER stress contributes to epithelial dysfunction in Z-AATD, resulting in enhanced inflammation. In addition, we hypothesize that the airways of Z-AATD patients are particularly prone to bacterial infection and colonization through…
The aim of this study is to evaluate whether there is a correlation between the sbN2-test, markers in exhaled air and the inflammatory cells in the small airways.