23 results
To evaluate image quality and accuracy of detection of perfusion defects associated with pulmonary pathology on iodine maps of the lung that are created by two different CT techniques: 1. A standard of care CTPA with DECT and 2. A new technique that…
To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
To study remodeling patterns of the left and right ventricle in patients with pulmonary arterial hypertension who underwent lung transplantation, using cardiac magnetic resonance imaging.
To demonstrate that MRI is as good in the detection of clinically relevant PAVM as the CT.
In this study we will therefore investigate the influence of hypoxia and anti oxidants on HVR and HPV.
The study investigates the role of the RV efficiency in the deterioration of RV function to failure in PH (measured with stroke volume index as the parameter of RV function); efficiency will be related to MVO2, alterations in substrate metabolism…
1. Does exercise training improve muscle function and exercise tolerance in patients with IPAH?2. Does exercise training in IPAH result in morphological and biochemical changes of the quadriceps muscle?3. Does exercise training in IPAH result in…
The main objective of the current study is to evaluate which patients in the twilight zone of PH will benefit from PAH specific therapy. We will assess the (early) response to PAH specific treatment and determine potential predictors of adverse…
To provide evidence demonstrating that ACT-guided heparin management during pulmonary thrombo-endarterectomy (PTE) involving cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) will result in inadequate heparinization and…
To establish a point prevalence of asymptomatic proximal lower extremity DVT in patients admitted to the ward with COVID-19.
To investigate whether increased vascular cell proliferation in the lung of PAH patients can be assessed using [18F]-FLT-PET/CT imaging.
Het primaire doel is het bepalen van de sensitiviteit en specificiteit van de MR Pulmonalis Angiografie (MRPA) waarbij de CT Pulmonalis Angiografie (CTPA) de gouden standaard is.** Als secundaire uitkomsten: het bepalen wat de klinische…
The primary aim of this study is to determine types and prevalence of residual pulmonary damage after hospital admission for acute COVID-19. In particular, we aim at determining the prevalence of clinically *silent* pulmonary perfusion abnormalities…
Primary Objectives• To identify circulating micro RNA biomarkers associated with pulmonary hypertension in blood samples.• To develop signatures for detecting patients at high risk of pulmonary hypertension to assist in the diagnosis of pulmonary…
The primary objective of the study is determine the effect of an 8-week standardized exercise training program in patients with persistent functional limitations 4 weeks after a diagnosis of acute PE, on physical performance (as assessed by the…
The main objective is to test if PH occurs in patients treated with thoracic radiotherapy and identify dose metrics and other risk factors for the development of PH after thoracic radiotherapy. In addition, changes in systolic and diastolic…
Primary Objective: To evaluate persisting pulmonary morbidity and echocardiographic signs of pulmonary hypertension in young adults born with CDH that interfere with physical fitness and participation in society.Secondary Objective(s): To evaluate…
We aim to assess differences in the in vivo distribution of CD8+ T-cells in patients with proven SARS-CoV-2 presenting with lymphopenia or with normal lymphocyte counts, using [89Zr]Zr-Df-IAB22M2C PET/CT imaging. Elucidating the pathophysiology…
Describe long-term changes in cardiorespiratory function and structure in a cohort of CTEPH and CTED patients treated with PEA and/or BPA in Denmark and the Netherlands.