59 results
To compare a ventilation strategy using higher levels of PEEP with recruitment maneuvers with one using lower levels of PEEP without recruitment maneuvers in obese patients at an intermediate-to-high risk for PPCs.We hypothesize that an intra-…
The present study aims at comparing a ventilation strategy with a lower tidal volume and a higher respiratory rate with ventilation using a higher tidal volume and a lower respiratory rate in ICU patients without moderate or severe ARDS.
The projects is divided in 3 aims: 1) To evaluate the regenerative capacity of lung-derived MSCs (LMSCs) from normal and emphysematous lung tissue and compare LMCSs to MSCs derived from other tissues2) To investigate the interaction of MSCs with the…
Reducing the number of readmissions in the revolving door patients diagnosed with COPD by means of an outreaching care nurse.
The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…
The primary objective is to compare the haemostatic effect of VHA-guided transfusion strategy versus optimized CCT guided transfusion strategy in haemorrhaging trauma patients. The secondary objectives of the study are to determine the effects of…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
Primary objectives of the pilot study• To determine childhood cardiovascular health in offspring of PCOS mothers and to compare it with children from non-PCOS mothers.Secondary objectives of the pilot study• To compare cardiovascular risk factors…
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
Primary Objective: To identify new clinical phenotypes in patients with severe chronic obstructive pulmonary disease (COPD) using a cluster analysis.Secondary Objectives: To:- identify clinical phenotypes (based on e.g. lung function parameters,…
Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
The present study aims at comparing the post-operative lung injury of a lung*protective mechanical ventilation strategy (with the use of higher levels of PEEP and intra*operative recruitment maneuvers) with conventional mechanical ventilation (lower…
* To define the characteristics of children with severe asthma and severe pre school wheeze in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma and wheeze* To repeat the…
Questions/aimsTo study the effects of dynamic hyperinflation on pulmonary hemodynamics and right and left ventricular function we formulated the following questions.Do COPD patients with dynamic hyperinflation have a more impaired response of stroke…
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
Evaluate the effect of intrathoracic pressure on right ventricular function in healthy subjects.
The primary aim of this project is to define the role exacerbations play in the pathophysiology of COPD. Moreover, the study has the aim to determine the long-term effects of PR and the natural course of the disease. The unique design of MCC will…