44 results
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
1. To predict the clinical course (in terms of occurrence of ALI and ARDS, duration of mechanical ventilation, need for renal replacement therapy, length of ICU-stay, length of hospital-stay, ICU-mortality, 30-day mortality) in patients after…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…
Primary Objective: To identify new clinical phenotypes in patients with severe chronic obstructive pulmonary disease (COPD) using a cluster analysis.Secondary Objectives: To:- identify clinical phenotypes (based on e.g. lung function parameters,…
The primary objective of this study is to determine the eosinophil lifespans under inflammatory conditions in the blood and lungs of patients with eosinophilic asthma
Questions/aimsTo study the effects of dynamic hyperinflation on pulmonary hemodynamics and right and left ventricular function we formulated the following questions.Do COPD patients with dynamic hyperinflation have a more impaired response of stroke…
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
Evaluate the effect of intrathoracic pressure on right ventricular function in healthy subjects.
* To define the characteristics of children with severe asthma and severe pre school wheeze in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma and wheeze* To repeat the…
* To define the characteristics of patients with severe asthma in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma, and healthy controls* To repeat the measurement of clinical…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
To investigate (1) whether basal levels of oxidative stress differs between COPD patients and healthy volunteers and (2) whether exercise-induced oxidative stress after a single-leg ergometer test differs between patients and healthy controls (3) to…
To measure markers of several pathways of apoptosis in broncho-alveolar lavage fluid in time during MV in children.
In this pilot study we intend to measure Tregs in umbilical cord blood, in normal as well as in pregnancies complicated by preeclampsia, and will define their use as a predictor of the risk for developing allergic diseases in the child.
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
Our primary goal is to compare the effects of a positive pressure mechanical ventilation with spontaneous breathing on systemic cytokine release in patients with normal pulmonary function. Secondly, the possible effects of surgery on the ventilation…
In this investigation the natural course of occupational allergy and asthma in bell pepper greenhouses is studied and the determinants of the development of sensitization and symptoms in the cohort of 472 employees, studied in 1999 are assessed.…