44 results
Primary objectives of the pilot study• To determine childhood cardiovascular health in offspring of PCOS mothers and to compare it with children from non-PCOS mothers.Secondary objectives of the pilot study• To compare cardiovascular risk factors…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
Primary Objective: To identify new clinical phenotypes in patients with severe chronic obstructive pulmonary disease (COPD) using a cluster analysis.Secondary Objectives: To:- identify clinical phenotypes (based on e.g. lung function parameters,…
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
Our primary goal is to compare the effects of a positive pressure mechanical ventilation with spontaneous breathing on systemic cytokine release in patients with normal pulmonary function. Secondly, the possible effects of surgery on the ventilation…
To test the hypothesis stated above, we propose to study the dose-response relationship between various chemostimulants and PMN functions of major trauma patients and patients undergoing major surgery in vitro, both early after the initial trauma or…
To investigate (1) whether basal levels of oxidative stress differs between COPD patients and healthy volunteers and (2) whether exercise-induced oxidative stress after a single-leg ergometer test differs between patients and healthy controls (3) to…
To measure markers of several pathways of apoptosis in broncho-alveolar lavage fluid in time during MV in children.
In this pilot study we intend to measure Tregs in umbilical cord blood, in normal as well as in pregnancies complicated by preeclampsia, and will define their use as a predictor of the risk for developing allergic diseases in the child.
To examine the apoptotic response of isolated and cultured airway epithelial cells of infants to a wide variety of cytotoxic agents and potential apoptotic stimulants ex vivo. These include oxygen, nitric oxide, peroxynitrite, cigarette smoke…
In this investigation the natural course of occupational allergy and asthma in bell pepper greenhouses is studied and the determinants of the development of sensitization and symptoms in the cohort of 472 employees, studied in 1999 are assessed.…
The primary aim of this project is to define the role exacerbations play in the pathophysiology of COPD. Moreover, the study has the aim to determine the long-term effects of PR and the natural course of the disease. The unique design of MCC will…
Intestinal Permeability during Respiratory insufficiency in patients with acute exacerbation of COPD
The primary objective of the present study is to investigate if the intestinal permeability is increased in patients with an acute COPD exacerbation. To investigate this objective, the following research question have been formulated:- Is intestinal…
The objective is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents.
The general objective of the Doetinchem Cohort Study is to contribute to the answering of public health questions, now and in the future, by providing basic data on developments in lifestyle and health problems in the general Dutch population.
This study will investigate fatigue after exercise in sarcoidosis patients. It will determine the severity of their fatigue, the recuperative capacity after maximal exertion (bicycle ergometer) and the levels of ACE and cytokines (before and after…
The primary objective is to study the level and time course of pulmonary pro- and anti-inflammatory mediators in children who need 2 hours of mechanical ventilation because they are undergoing an elective procedure.
Primary Objective: We will investigate the following primary research questions:1. What are exposomic factors that predict the maximum attained level of lung function? 2. What are genetic predictors of the maximum attained level of lung function? 3…
As highlighted, significant gaps in knowledge remain regarding etiology of cough, consequences of cough and appropriate treatment of cough in patients with pulmonary fibrosis. A further understanding of the similarities and differences in cough…
The primary objective is to assess the role of obstructive sleep apnea related pathophysiological mechanisms in the initiation of atrial fibrillation by a multi-parametric strategy that combines the estimated parameters. The main hypothesis is that…