12 results
Primary Objective: To investigate the effect of treatment with nebulized rhDNase on pulmonary function in children with asthma and persistent obstructive pulmonary function.Secondary Objectives: To investigate the effect of treatment with nebulized…
The primary objective is the Objective tumor response rate (RECIST). Secondary objectives are: duration of overall response, time to tumor progression (TTP), progression free survival (PFS), overall survival, toxicity profile, incidence of…
The objective of this trial is to demonstrate that bosentan delays disease worsening or death in patients with IPF.
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
To investigate (1) whether basal levels of oxidative stress differs between COPD patients and healthy volunteers and (2) whether exercise-induced oxidative stress after a single-leg ergometer test differs between patients and healthy controls (3) to…
The obtained FOT parameters can distinguish the group of COPD patients with expiratory flow limitation in body plethysmography from the patients without expiratory flow limitation in body plethysmography.
In this pilot study we intend to measure Tregs in umbilical cord blood, in normal as well as in pregnancies complicated by preeclampsia, and will define their use as a predictor of the risk for developing allergic diseases in the child.
Primary Objective: To perform BAL in healthy volunteers, who can serve as control subjects in (future) studies.
Main: To evaluate the safety and effectiveness of the Exhale Drug-Eluting Stent (DES) to improve pulmonary function for homogeneous emphysema subjects with severe hyperinflation, in a prospective, randomized, Sham-controlled, double-blind, multi-…
To study the possible relation between systemic inflammation and oxidative stress and muscle breakdown using pharmacological interventions.
To examine the apoptotic response of isolated and cultured airway epithelial cells of infants to a wide variety of cytotoxic agents and potential apoptotic stimulants ex vivo. These include oxygen, nitric oxide, peroxynitrite, cigarette smoke…
In this investigation the natural course of occupational allergy and asthma in bell pepper greenhouses is studied and the determinants of the development of sensitization and symptoms in the cohort of 472 employees, studied in 1999 are assessed.…