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Assessment of inflammatory response of bronchial cells to gastric juice from hospitalized infants on and off proton pump inhibitor (PPI) therapy, PICU admitted children and long term users (0-18 years) of PPIs and controls off PPI

Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…

Investigation of the applicability of dry powder inhalation in children with cystic fibrosis

The main objective is to determine whether children with CF are able to achieve an inhalation manoeuvre as required for aerosol generation and transport into the peripheral airways with the test inhaler. The secondary objectives are to determine…

A Phase 2, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of
Inhaled JNJ-49095397 (RV568) in Subjects With Moderate to Severe Chronic Obstructive
Pulmonary Disease

Primary ObjectiveThe primary objective is to assess the efficacy (as measured by change from baseline in prebronchodilator [preBD] percent predicted forced expiratory volume in one second [FEV1]) of JNJ-49095397 compared with placebo in subjects…

Gene expression during ciliagenesis: Towards a novel candidate gene list for Primary Ciliary Dyskinesia

We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.

Effect of Carbon Dioxide Enriched Ambient Air on Pharmacokinetics and Deposition In Bronchiectasis Patients Using Tobramycin Inhalation: A proof of concept study.

1. To asses (with planar imaging) whether SPECT/CT scan are feasible in assessing pulmonary deposition of inhaled tobramycin.2. To evaluate the effect of CO2 enriched ambient air on deposition of inhaled tobramycin in bronchiectasis patients.3. To…

MOSAIC study:
MOdel to Study upper Airway Immunity upon Cholera vaccination

To investigate whether raw milk is able to enhance the upper airway immune response as induced by oral cholera vaccination.

Addition of Tobramycin inhalation antibiotic treatment to standard IV antibiotic treatment for ventilator-associated pneumonia

Does addition of inhalation tobramycin to standard IV treatment result in a higher clinical cure rate than standard IV antibiotic treatment alone in patients with ventilator-associated pneumonia.The initial response to treatment will be evaluated…

An open-label, single-arm study to determine the excretion balance and metabolic disposition of [14C]GW642444 administered as a single dose of an oral solution to healthy male volunteers

Primary:To compare total radioactivity (drug-related material) in plasma relative to parent plasma GW642444 concentration following a single oral dose (200µg) of [14C]-GW642444 in healthy male subjects.To determine the rate and extent of excretion…

Venturius study
Epidemiology, genetics and immunology of viral lower respiratory tract infections in children.

Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.

A randomized, double-blind, placebo controlled, parallel group, multi-centre, 2-week treatment study to evaluate the safety and efficacy of fluticasone furoate nasal spray (FFNS) 110 mcg, administered either once daily or twice daily, compared with placebo, as effective monotherapy in the treatment of uncomplicated acute rhinosinusitis (ARS) in adult and adolescent subjects 12 years of age and older.

The objective of this study is to evaluate the safety and efficacy of two doses of FFNS (110 mcg once daily and 110 mcg twice daily) compared to placebo as monotherapy in the treatment of adult and adolescent subjects 12 years of age and older with…

Lung inflammation and injury during mechanical ventilation for respiratory syncytial virus induced respiratory failure in infancy

The primary objective is to study the level and time course of lung inflammation and lung injury of ventilated infants with RSV LRTD. Secondary objective include studying the correlation between the level and time course of lung inflammation and…

*Microbiological evaluation of BAL fluid from patients with nosocomial Pulmonary Aspiration Syndrome compared to BAL fluid from hospitalized patients undergoing inspection bronchoscopy. A pilot study.*

Validation of microbiological analyses of BAL (broncho alveolar lavage) fluid in patients suspected of nosocomial bacterial aspiration pneumonia.

The effect of severe respiratory syncytial virus (RSV) lower respiratory tract infections in mechanically ventilated infants younger than 12 months of age on recurrent wheezing and lung function

The primary objective is a) to study the occurrence of recurrent wheezing following hospitalisation for severe RSV LRTD, and to study the differences in occurrence between ventilated and non-ventilated infants, and ) to study differences in lung…

The Genetic variability in the host response to community-acquired pneumonia

To determine the genetic risk of susceptibility to, or severity of community-acquired pneumonia by comparing the interpersonal genetic variation of the host immune response of patients with community-acquired pneumonia to healthy controls and by…

Childhood study on respiratory pathogens from induced sputum

To determine the effectiveness of sputum induction in retrieving good quality sputum, identifying bacterial and viral pathogens in lower respiratory tract infections and determine the practical applicability of sputum induction in general pediatric…

Skin Autofluorescence and Capillary Permeability: Relevance of Measuring Advanced Glycation Endproducts in Critically Ill Patients

Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.

A multi-center, randomized, double-blind, placebo-controlled, parallel group, repeated-dose study to evaluate the efficacy, safety, tolerability and pharmacokinetics of three different dosing regimens of inhaled indacaterol maleate in patients with persistent asthma

The purpose of this study is to give more information about indacaterol in similar doses but given either once a day, twice a day, or once every other day to patients with persistent asthma.

Exercise training in patients with COPD

To quantify the effectiveness of one- legged exercise training in improving functional status of patients with COPD in comparison to two- legged exercise training during a 10 week pulmonary rehabilitation programme.

The role of innate immunity in the pathogenesis of acute respiratory syncytial virus lower respiratory tract infection:
Repeated measurements of nasopharyngeal type 1 interferon levels in RSV infections

To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…

Pulmonary function after mechanical ventilation for respiratory syncytial virus induced respiratory failure in infancy

Primary Objective: *To study differences in pulmonary function (i.e. increased airway resistance) one year after hospitalisation for RSV LRTD between mechanically ventilated and non-ventilated infantsSecondary Objectives: *To study…