79 results
1. To assess the incidence of pulmonary infiltrates by means of low dose CT-scan in patients with a high clinical suspicion of CAP but with a normal chest x-ray 2. The levels of biomarkers (CRP, PCT, White blood cell count) will be compared to the…
This research project aims to determine the feasibility of setting up a randomized controlled trial to study the effects of different fluid management protocols on the outcome of mechanically ventilated pediatric patients with acute infectious lung…
To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.
1. To assess the clinical value of ULDCT as compared to CXR examinations for diagnosing pulmonary pathology.2. To identify patient groups or indications that may benefit by replacing CXR by ULDCT examination. 3. To analyze the effect of…
This study is designed to test if consumption of a vegetable extract as a food ingredient improves resistance to an experimental respiratory tract infection with RV16 in healthy volunteers.Primary Objective: * To test and quantify the effect of the…
Objective: The main objective is to establish the strength of the relationship between improvements in dyspnea and health related Quality of Life (HR-QoL) with the decrease in hyperinflation during the resolution of a COPD exacerbation in the…
Primary objective: To assess the influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of pneumonia in physically-impaired care home residents with dysphagia.Secondary…
To investigate if ultra low-dose chest CT may be a better diagnostic tool than chest X-ray on day 1 of febrile neutropenia. Imaging results will be compared with a consensus diagnosis on the cause of febrile neutropenia made by an expert panel.…
To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.
Investigate if preoperative IMT affects the incidence of postoperative pneumonia after esophageal resection.
Objectives: The primary objective is to establish whether expiratory VOC analysis by electronic nose and GC-MS can: Ia) discriminate between patients (CF, PCD) with and without an exacerbation and Ib) discriminate between different microbial species…
The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.
The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…
Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…
The aim of the CO-PRINCE study is to establish the efficacy and safety of long-term antibiotic prophylaxis with co-trimoxazolein children with recurrent upper and/or lower respiratory tract infections (including ear-nose-throat (ENT)).
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
Primary Objective: to determine the feasibility of supported MV with low tidal volumes after partial neuromuscular blockade in patients with high respiratory drive. Secondary Objective: to determine the effect of partial neuromuscular blockade on…
To assess the effect of vitamin D supplementation on pulmonary function, the incidence of exacerbations and physical performance in patients with COPD.
OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.
Primary Objective: • To determine the incidence rate of self-reported ILI.Secondary Objectives: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported LRTI.• To explore the effect of 13vPnC on the incidence of self-…