66 results
Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…
We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
The primary objective is to study the level and time course of lung inflammation and lung injury of ventilated infants with RSV LRTD. Secondary objective include studying the correlation between the level and time course of lung inflammation and…
Validation of microbiological analyses of BAL (broncho alveolar lavage) fluid in patients suspected of nosocomial bacterial aspiration pneumonia.
The primary objective is a) to study the occurrence of recurrent wheezing following hospitalisation for severe RSV LRTD, and to study the differences in occurrence between ventilated and non-ventilated infants, and ) to study differences in lung…
To determine the genetic risk of susceptibility to, or severity of community-acquired pneumonia by comparing the interpersonal genetic variation of the host immune response of patients with community-acquired pneumonia to healthy controls and by…
To determine the effectiveness of sputum induction in retrieving good quality sputum, identifying bacterial and viral pathogens in lower respiratory tract infections and determine the practical applicability of sputum induction in general pediatric…
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
The objective of this study is to evaluate the reproducibility (CV) of a 6-minute cycle exercise performance test in patients with COPD.
To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…
Primary Objective: *To study differences in pulmonary function (i.e. increased airway resistance) one year after hospitalisation for RSV LRTD between mechanically ventilated and non-ventilated infantsSecondary Objectives: *To study…
The aim of this study is to compare the time course of cytokines (markers for inflammation) in the following 3 groups: RSV-positive, ventilated patients; RSV-positive, non-ventilated patients and RSV-negative, ventilated patients. The main…
The researchquestion of this study:Is there an association between the respiratory and cardiovascular system in early childhood? If there is an assocation, what are its determinants?
Objectives: The aim of this study is to:I Identify pathogenic mutations in novel genes, causing PCDII Develop a diagnostic PCD test, based on MPSIII Validate MPS technique for PCD.
1. To investigate the etiology and incidence of respiratory tract infection in children younger than 6 years of age.2. To investigate the course of respiratory tract infections in children younger than 6 years of age.3. To investigate the clinical…
Improve the insight in the aetiology of CAP by season and by population in the Netherlands by the use of an extensive combination of microbiological techniques.Moreover this study will provide an unique sample from a well defined patient population…
The first aim of the study is to determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls. The second aim is to value…
Determine associations between genetic variation and immune response in nasopharyngeal aspirates of infants with RSV LRTI.
1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…