261 results
In this study we want to show adequate sputum levels are obtained throughout the day after inhalation of nebulized amoxicillin clavulanic acid in hospitalized AECOPD patients.
This study aims to relate factors of hypercoagulability, inflammation or general illness itself (all during ICU admission) to microstructural and microvascular abnormalities on follow-up brain advanced 3T and 7T MRI in COVID-19 ICU survivors. By…
The primary objective is to demonstrate a difference in the proportion of patients with progressed/worsened disease state in patients receiving FX06 compared to patients receiving placebo until day 28.Assessment and treatment comparison of the…
Primary objective:I. To explore what (bio)markers from a panel of (bio)markers (symptoms, vital signs, lung function and biosamples of sputum, nasal swabs, stools and blood) measured frequently predict an (preclinical) exacerbation and/or…
Study A: Validation of productive infection of RSV CHIMStudy B: Effectiveness and immunogenicity of local administration of palivizumab on prevention of experimental RSV infection
To determine whether convalescent plasma collected from donors who have recovered from COVID-19 and who have a very high titre of anti-SARS-CoV-2 antibodies reduce the risk of hospitalization or death due to COVID-19 in patients with early symptoms…
To determine the effect of hypertonic saline inhalation and best supportive care versus best supportive care alone on clinical efficacy measures in patients with nodular-bronchiectatic M. avium complex pulmonary disease, as measured by changes in…
To investigate the dynamics of IgA and IgG antibody level against SARS-CoV-2 in 86 health care workers with relatively mild symptoms.
To evaluate the physiological effects, feasibility, tolerability and safety of CPAP via a face mask in patients with COVID-19 pneumonia requiring high inspired oxygen fractions during spontaneous breathing.
Demonstrate that iodine treatment has a beneficial effect on the course of COVID-19 disease. Beneficial effect is defined as less critically relevant deterioration such as transfers from regular to intensive care units, fewer days of hospitalization…
The overall aim of this study is to assess the multidimensional health status of COVID-19 survivors one year post-infection using validated subjective and objective measures.
This study has been transitioned to CTIS with ID 2023-507889-89-00 check the CTIS register for the current data. REMAP-CAP: The goal of the study is to investigate the best treatment regime for pneumonia patients. For non-pandemic pneumonia (…
Objective: The overall aim of this pilot study is to determine the diagnostic accuracy of exhaled breath analysis by eNose for the discrimination between patients and health care workers with and without Covid-19 at point of care.
Primary Objectives:1. To determine the proportion of patients with any of various predefined lesions suggestive of old TB infection detected by ULDCT in patients with LTBI as defined by TST or IGRA result, but without any LTBI-lesions on CXR2. To…
To investigate the feasibility of measuring the oxygen saturation at home by pulse oximetry as added to usual (primary) care in patients with or at risk of cardiovascular risk who have moderate to severe symptoms of (presumably) COVID-19 as compared…
To assess existing background immunity for respiratory virus stems in the general population.
To investigate the natural course of smell alterations in relation to COVID-19. To investigate differences in neuroanatomical structures (olfactory bulb) and neural activity between patients with anosmia and parosmia
Study A: Safety of intranasal administration of palivizumab in healthy adultsStudy B: Effect of local administration of palivizumab on prevention of RSV infection
In addition to the aforementioned passive monitoring of high-risk persons with respiratory complaints after exposure to HPAI, this project aims to set up active monitoring (exclusion diagnosis) in high-risk persons without respiratory complaints in…
Primary:Compare the efficacy of single IV injection with otilimab 90 mg in adults with severe pulmonary COVID-19 related disease.Secondary:Other aspects of efficacy. Safety and tolerability.