198 results
To validate FDG-PET segmentation tools for radiation target volume definition by correlation of CT and FDG-PET volume measurements with histology of nodal metastases of squamous cell carcinoma of the head and neck.
Development of a new technics to improve the diagnostic value of an EUS procedure in combination with reducing the amount of biopsies.
The objective of this study is to investigate the evolution of the 18F-deoxyglucose (FDG) uptake and the tumour characteristics determined in the plasma of patients with lung cancer during and after concurrent radiotherapy and chemotherapy.
To assess tumor reponse with FDG-PET-CT imaging early after start of concomitant chemo-radiotherapy in relation to cytological, histological and biological tumor characteristics. The ultimate goal is to reveal more insight in tumor reponse assesment…
This study aims to compare the accuracy of staging with integrated PET-CT and EUS-FNA and/or EBUS-TBNA in patients with operable non-small cell lung cancer compared to perioperative mediastinal lymph node dissection/ systematic lymph node sampling.
The objective of the present study is to investigate whether a metabolic response as assessed by 18F-FDG PET can be observed after the first fraction of SBRT. This study will contribute to establishing the role of definitive SBRT in the treatment of…
To asses wheter minimally invasive echo-endoscopic staging by the combination of EUS-FNA (esophagus) and EBUS-TBNA (bronchi) detects more lymph node metastases compared to conventional surgical staging.
To compare respiratory waveforms generated using reflective markers located on the upper abdominal wall (the currently used Varian RPM system) with either magnetic sensors, belt sensors or both placed on the chest wall and/or upper abdomen. The…
The main objective of this study is to find a correlation between the rise in NT pro BNP level and the radiation dose given to the heart.
Investigate the phenotype, function and regulation of TRM in healthy human lung tissue, lung tumors and peripheral blood to improve the understanding of respiratory diseases and adoptive T-cell therapy for lung cancer.
The purpose of this study is to assess the feasibility of the clinical use of 3T MR imaging for early glottic carcinoma.
The proportion of patients with a successful EUS-B-FNA procedure for LAG analysis
To determine the toxicity of adding chloroquine in escalating doses in patients with small cell lung cancer to standard therapy.
Primary objective: the assessment of the maximal mean lung dose that is accepted to safely treat large peripheral tumors or 2 lung metastases simultaneously using SBRT. Secondary objectives:- evaluation of local control - evaluation of regional…
The aim of the study is to evaluate the change of lung function at least one year after definitive chemoradiation (concurrent or sequential) in patients with locally advanced (non) small cell lung carcinoma to assess late radiation injury in our…
Primary ObjectiveTo establish a prospective cohort of patients undergoing radiotherapy for breast, prostate or lung cancers following local regimens and collecting standardised radiotherapy toxicity data, non genetic risk factor data and samples for…
The primary objective is to evaluate the ability of afatinib to control disease in pretreated patients with advanced non-small cell lung cancer harbouring HER2 exon 20 mutations.Secondary objectives are:* To evaluate secondary measures of clinical…
Primary objective:• To assess the safety and feasibility of adding ipilimumab-nivolumab to a CRT induction protocol• To assess the efficacy of adding ipilimumab-nivolumab to CRT on the likelihood of a pCR and MPRSecondary objectives: • Local and…
To investigate the progression-free survival after radiotherapy to a single lesion in patients with stage IV non-small cell lung cancer who achieved at least stable disease with immune therapy alone or concurrent immune therapy and chemotherapy and…
In this study, the aim is to derive optimal imaging procedures and to assess the technical performance of the Vision Quadra PET/CT system concerning its feasibility to detect indeterminate lung nodules. Furthermore, this study aims to preliminary…