20 results
We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…
zie nederlandse samenvatting
This study aims to investigate the process and outcome of the implementation of a coaching intervention in COPD care in the Friesland province.
To evaluate an intervention to improve medication intake behaviour in adolescents with asthma.
Primary objective:The primary objective is to answer the question: How do COPD patients experience intensive care unit admission because of exacerbation and what is the impact on their quality of life. This study aims to understand the perspective…
The development of a practical COPD disease severity index developed and validated in primary care settings and thus ready-for-use in primary care after completion of the proposed project.
Besides more basic research into which RNA-binding proteins and microRNAs regulate the expression of inflammatory mediators in airway epithelial cells, we will also assess these proteins and microRNAs in airway epithelial cells from patients with…
To investigate whether cough measurements by means of VAS (0-100 points) after 6 months (+/- 6 points) in patients with chronic cough who are diagnosed and treated by a nurse practitioner outpatient clinic are equal to an outpatient clinic leaded by…
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
The primary objective is to quantify the overall success rate of intubation in prone position through an I-gel LMA.The secondary outcomes are time for insertion of the I-gel LMA, time for intubation, glottic view obtained by the VSSL, manoeuvres…
The purpose of the registry is to determine disease development of advanced and non-advanced sarcoidosis. In addition, the registry would note the other organ involvemen, treatment and quality of life.
By using advanced respiratory monitoring, we will aim to gain more understanding about the physiological effects and potential benefits of FCV in comparison to PCV in patients with moderate to severe ARDS. We hypothesize that FCV results in a lower…
The primary objective of this study is to evaluate the feasibility of MI-E in invasively ventilated critically ill patients. The secondary objective is to evaluate safety and explore data on the efficacy of MI-E in invasively ventilated critically…
The overall aim of the study is to improve personalized medicine for patients with severe asthma through the investigation of possible immunological mechanisms responsible for non-response or incomplete response to biological treatments.2.1 3TR -…
The aim of this project is to test the hypothesis that symptom-free days (SFDs) of children with preschool wheezing can be increased using Luchtbrug Junior, while reducing regular outpatient visits by 50%.
In the present pilot study, we intend to test phenotypic flexibility (Phenflex) in 20 clinically stable patients with COPD by exploring their response to a dietary challenge test before and after pulmonary rehabilitation. Moreover, the…
Studies have shown that generation of lung cells from human pluripotent stem cells is possible. The present study aims to develop cell cultures, such as 3D mini lung structures from skin cells from subjects with ILD and/or their family members. The…
An Open-label Extension Study of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis
To evaluate the long-term safety and tolerability of inhaled treprostinil in subjects with IPF.
The aim of the EXACT@Home study is to further improve the assessment of treatable traits in patients with difficult to treat to severe asthma using ehealth before considering treatment with biologics.
Remimazolam for long-term sedation during invasive mechanical ventilation in critically ill patients
To elucidate whether a sedation regimen with remimazolam can reduce the ICU length of stay in critically ill patients with renal failure, compared to patients treated with a sedation regimen with midazolam.