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Diaphragm-protective mechanical ventilation in critically ill patients: A proof of concept study.

Primary objective of this study is to assess the feasibility of using a monitoring and a titration algorithm to prevent inactivity and excessive activity of the diaphragm. This will be determined by comparing the fraction of breaths where diaphragm…

Endobronchial vs. esophageal ultrasound for diagnosing sarcoidosis: A randomized clinical trial;
A standard vs ProCore Needle comparison

1. Esophageal ultrasound guided (EUS-B) sampling of intrathoracic lymph nodes has a14% higher granuloma detection rate compared to endobronchial ultrasound (EBUS)guided nodal sampling in patients with suspected sarcoidosis stage I/II.2. 25G ProCore…

Immunity to varicella-zoster virus in patients before and after lung transplantation

Objective of the study is to evaluate efficacy of VZV vaccination in lung transplantation patients, intended to prevent morbidity by VZV infection. Efficacy of vaccination will be measured by means of determining cellular immunity to VZV. Cellular…

Sonographic assessment of diaphragm function during inspiratory loading.

We hypothesize that speckle tracking sonography of the diaphragm is a potential non-invasive method to evaluate diaphragm function. The objective is to evaluate whether speckle tracking sonography of the diaphragm gives a good representation of…

Imaging lung lymphocytic infiltration with radiolabelled Interleukin-2 in the follow-up of patients with lung transplantation; a marker of acute rejection

To evaluate the ability of the IL-2 scan tot detect the presence of acute rejection in the transplanted lungs and the correlate the uptake of IL-2 with the histopathological findings after transbronchial biopsy.

The Cardio Thoracic Harness

The objective of this study is to get insight in the effect of the Cardio Thoracic Harness for men and the Cardio thoracic bra for women. The harness and the bra possibly have an important role in pain management. The producer of the harness and the…

Visualization of regional lung ventilation using Electrical Impedance Tomography (EIT)

Primary Objective: To study the options of the PulmoVista 500 system to visualize regional real-time lung ventilation in healthy volunteersResearch questions:- Can the PulmoVista 500 system provide sufficient information regarding regional lung…

PRone positioN in patients with
spontanEous ventiLation and
acute hypoxemic respIratory
FailurE- The PRONELIFE
Randomized Controlled Trial

PRONELIFE is the first randomized controlled trial comparing the prone position with the supine position in patients with acute hypoxemic respiratory failure from any cause that recruits a sufficient number of patients to test the hypothesis that…

Effects of COVID-19-infection on movement and tissue characteristics of the diaphragm visualized by magnetic resonance imaging: a proof-of-concept study

The primary goal is to evaluate the difference between diaphragm tissue characteristics and movement in extubated COVID-ICU patients after >72 hours of invasive mechanical ventilation compared to other ICU-patients and healthy controls.…

Diaphragm electromyography to estimate breathing effort and fatigue : a physiological study

1). Develop a model in which the electrical activity of the diaphragm (EAdi) is used to predict the transdiaphragmatic pressure (Pdi) 2) Assess to which degree this model is accurate in estimation Pdi-derived parameters (such as work of breathing…

Breath synchronized electrical stimulation of the abdominal wall muscles to prevent respiratory muscle atrophy during the acute stages of mechanical ventilation therapy

The primary objective of this study is to investigate whether electrical stimulation applied to the abdominal wall muscles in synchrony with exhalation can be feasible to prevent the development of atrophy of the abdominal wall muscles during the…