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Control of breathing in systemic sclerosis

-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…

'Evaluation of respiratory muscle function after posterior scoliosis surgery, using dynamic MRI and exercise tests'

I. To evaluate what the impact is of posterior scoliosis correction on respiratory muscle function (strength, endurance, power and work of breathing).II. To evaluate the relation of changes in respiratory muscle function, due to the posterior…

The Cardio Thoracic Harness

The objective of this study is to get insight in the effect of the Cardio Thoracic Harness for men and the Cardio thoracic bra for women. The harness and the bra possibly have an important role in pain management. The producer of the harness and the…

PRone positioN in patients with
spontanEous ventiLation and
acute hypoxemic respIratory
FailurE- The PRONELIFE
Randomized Controlled Trial

PRONELIFE is the first randomized controlled trial comparing the prone position with the supine position in patients with acute hypoxemic respiratory failure from any cause that recruits a sufficient number of patients to test the hypothesis that…

Anaerobic threshold in patients with pectus excavatum

The objective of this study is to demonstrate the influence of pectus excavatum on the anaerobic threshold during exercise. This could be an objective measurement of exercise intolerance. An objective measurement of exercise intolerance can later…

Effect of palivizumab on respiratory syncytial virus-associated burden of disease - a randomized controlled trial

It is not known whether recurrent wheeze in preterm children is caused by RSV infection (serial hypothesis) or that RSV infection is the first indication of chronic airway morbidity that would develop anyway (parallel hypothesis). This study aims to…

Immunity to varicella-zoster virus in patients before and after lung transplantation

Objective of the study is to evaluate efficacy of VZV vaccination in lung transplantation patients, intended to prevent morbidity by VZV infection. Efficacy of vaccination will be measured by means of determining cellular immunity to VZV. Cellular…

Breath synchronized electrical stimulation of the abdominal wall muscles to prevent respiratory muscle atrophy during the acute stages of mechanical ventilation therapy

The primary objective of this study is to investigate whether electrical stimulation applied to the abdominal wall muscles in synchrony with exhalation can be feasible to prevent the development of atrophy of the abdominal wall muscles during the…

Diaphragm-protective mechanical ventilation in critically ill patients: A proof of concept study.

Primary objective of this study is to assess the feasibility of using a monitoring and a titration algorithm to prevent inactivity and excessive activity of the diaphragm. This will be determined by comparing the fraction of breaths where diaphragm…