Search for a trial

Effect of a Platelet Rich Plasma (PRP) injection on the outcome of chronic lateral epicondylitis.
A double blinded randomized controlled clinical trial.

The effectiveness of PRP treatment in patients suffering from chronic lateral epicondylitis is still ambiguous. Therefore we study PRP treatment in a double blind randomized controlled trial in a homogeny patient population with respect to duration…

The effect of Body temperature regulation on host response in patients with Septic shock
(A sub-study of the CASS study)

Primary: To determine the effects of MIH on circulatory, inflammatory and metabolic aspects of host response to sepsis.Secondary: To determine if MIH prevents and/or decreases the severity of ICU-AW in septic shock.

Neurotoxic adverse effects of morphine and oxycodone in continuous subcutaneous infusion for treatment of pain in terminal patients with diminished renal function: a Randomized Controlled Trial.

The primary objective of this study is to compare the prevalence of delirium between oxycodone and morphine, administered by CSCI, for the treatment of pain in dying patients with a diminished renal function.The secondary objective is to compare the…

Can Mild Induced Hypothermia reduce mortality in septic shock patients at the Intensive Care Unit?
A randomized, single-blinded, multicenter study. The cooling and surviving septic shock study

To investigate whether cooling to 33 °C for 24 hours in septic shock reduces mortality in intensive care patients.

A randomized, single blinded trial to evaluate the efficacy of Imiquimod in women with residual/recurrent Cervical Intraepithelial Neoplasia (CIN) after previous treatment

Primary objectives: Evaluation of the efficacy of imiquimod 5% cream compared to treatment with Large Loop excision of the transformation zone (LLETZ) for recurrent/residual CIN.Secondary objectives: evaluation of the effect of treatments on HPV DNA…

Sitagliptin prophylaxis for glucocorticoid-induced impairment of glucose metabolism and beta-cell function in males with the metabolic syndrome-X: a randomized, placebo controlled, double blind, 2x2 factorial designed intervention trial.

The objective of this study is to assess whether sitagliptin may prevent prednisolone-induced impairment of glucose metabolism and beta-cell function.

A randomized, double-blind, placebo-controlled, serial-cohort, single ascending dose of Xen2174 PK/PD study administered intrathecally in healthy volunteers.

The objectives of the study are:To determine the pharmacokinetic profile of Xen2174 in plasma and CSF when administered intrathecally to healthy volunteersTo determine which modalities of pain are affected by treatment with Xen2174 when administered…

A randomized, double-blind, placebo-controlled, serial-cohort, single ascending dose of Xen2174 with bupivacaine interaction study administered intrathecally in healthy volunteers.

The objectives of the study are:To determine the pharmacokinetic and pharmacodynamic interaction of a single ascending dose of Xen2174 with bupivacaine, and in one cohort of Xen2174 alone, when administered intrathecally to healthy volunteers and…

Preventive Methods for Reduction of Pain associated with Propofol Injection: a randomised controlled trial of commonly used methods

In this randomised controlled trial we compare three commonly used preventive methods to reduce the pain on injection op (PIP) with a control group. Our primary goal is to try and establish the most effective and easy to use method for preventing…

Treatment of Chronic Idiopathic Cough (CIC) and Chronic Cough in patients with Idiopathic Pulmonary Fibrosis (IPF) with PA101.

The objectives of the study are as follows:*1. To assess the effectiveness of inhaled PA101 delivered via eFlow high efficiency nebulizer for treating chronic cough. Improvements in chronic cough will be assessed by measuring the change from…

Brimonidine Tartrate for the Treatment of Injection Related Erythema Associated with Sub-cutaneous Administration of Peginterferon beta-1a

Primary ObjectivesTo evaluate the IRE intensity/color mitigation effect of a single administration of Brimonidine tartrate in comparison with a vehicle gel (placebo).Secondary ObjectiveTo evaluate the IRE intensity/color mitigation effect of a…

Protein intake, gastro-Intestinal tolerance and safety after administration of a new high protein tube feed in critically ill overweight ICU patients as compared to an isocaloric standard tube feed.

As meeting protein requirements seems to be very important in critically ill patients, the primary objective of the current study is to investigate protein intake with the new tube feed.

Finding best practice: use of s-ketamine peropertively and in patient controlled analgesia in the treatment of pain after major abdominal surgery

1.To compare the morphine sparing effect of low-dose ketamine in peroperative infusion and in post operative PCA (Morphine use)2.To compare the occurence of side effects.3.To compare the analgesic potential of the two therapies (VAS Scores)4.To…

Ascending single dose study of the safety, tolerability, and pharmacokinetics of PRM-151 administered to healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF)

PRM-151 is being developed for potential therapeutic uses to prevent, treat, and reduce fibrosis. This study will provide an initial assessment of the safety, tolerability, and pharmacokinetics (PK) of PRM-151 after administration of ascending…

Wountherapy in patienten with a sinus pilonidalis using a VAC-therapie versus Kerlix-gauze.

To show the differrence of total healing of wound between two therapies, VAC and gauze-therapy, in patient with a sinu pilonidalis after chirgical intervention.

*Does maintaining endotracheal tube cuff pressures at 20 mm Hg prevent dysphagia and hoarseness after anterior cervical spine surgery?*
A randomised controlled trial.

To determine if adjusting endotracheal tube cuff pressure after placement of a retractor during anterior cervical spine surgery prevents postoperative dysphagia. Furthermore laryngo-tracheal complaints (hoarseness and sore throat) will be scored.

The effect of glycopyrroniumbromide on nocturnal clozapine induced sialorrhea in psychiatric patients: a randomized, cross-over, double blind, placebo controlled trial with an extended open label phase (QUITSPIT study)

Main objective: to determine the effect, defined as the percentage of patients that show a clinical relevant improvement on the severity of complaints of nocturnal sialorrhea, of oral glycopyrroniumbromide in comparison with placebo in psychiatric…

Developing an experimental paradigm for assessing the effects of physician-patient communication on patients* health status

To test if viewing a medical consultation on video leads to comparable psychological and physiological responses to the communication as being a patient in that consultation.

The peripheral effects of prednisolone on glucose metabolism, metabolic hormones, insulin sensitivity and insulin secretion in healthy young males and males with metabolic syndrome * two randomized, placebo controlled, double blind, dose-response, parallel group intervention studies.

The objective of these studies is to identify the primary mechanisms of GC-induced dysmetabolic effects in humans and to find biomarkers that reflect these side effects of GC treatment and which can be followed during therapy and in future clinical…

Perioperative urinary output and course of diuresis during outpatient treatment under general anesthesia.

Main question:Does a restrictive fluid management during general anesthesia lead to less urinary production?Sub questions:Does a fluid management with colloid fluid during general anesthesia lead to a change in urinary production?Does a different…