31 results
In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.
Primary objective- Short- and mid-term repeatability of mDLS and LSCI measures;- Comparison of blood flow obtained by LSCI and blood flow obtained by mDLS;- Comparison of coagulation status obtained by mDLS and coagulation status assessed by…
In this study, we will test which of two feeding strategies for adults during chemotherapy-induced mucositis is optimal with regards to maintaining an optimal body weight, nutritional status, gut mucosal barrier and treatment outcome (including…
More sustained knowledge of the intracellular processes regarding S1P in lymphocytes could be beneficial in modulating specific immune responses in transplantation medicine, autoimmune diseases and sepsis. Therefore, in this study, we will…
Assessment of the cutaneous and retinal microcirculation in SCD patients and matched controls:- Long- and short-term repeatability of LSCI and NiRFI ;- Comparison of cutaneous and retinal microcirculation between SCD patients and matched healthy…
The aim of this research is to improve the understanding of the coagulation system through a detailed characterization and quantification of biosynthesis and expression of several coagulation proteins in BOECs. The data obtained in the study will be…
The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…
This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…
We aim to evaluate the use of MRDTI in the diagnosis of acute proximal DVT, comparing the findings with CUS. To evaluate the outcome of patients with positive and negative MRDTI and CUS, clinical outcome after 3 months of follow-up will be measured…
The purpose of the present study is to examine the perception of immigrant parents of their child*s beta thalassemia and the provided care during treatment with stem cell transplantation in the Netherlands. It is important to study and learn about…
Primary objective:To determine the hepcidin levels before, 2, 4, 8 and 24 hours after the administration of anti-IL-6R in patients with RA.Secondary objective:To determine the levels of Iron, transferrin , (calculation of transferrin saturation),…
Determine the ADAMTS-13 activity in patients with a history of TTP.
Purpose: Determine the ADAMTS-13 activity in patients with a history of TTP.
The main purpose of the study is to assess immune cell dynamics in Tecfidera-treated MS patients and untreated healthy subjects, and to explore whether differences in immune cell dynamics exist between both populations. The data generated in this…
Primary Objective: To compare the extent of haemolysis associated with the use of the conventional versus the miniaturised heart lung machine in the Amphia hospital, with the aim to set up evidence-based guidelines for the use of a specific type of…
Primary aim:- What is the increase in hemoglobin concentration between epoetin alpha injection number three and four in patients awaiting orthopedic surgery?Secondary aim:- What is de increase in hemoglobin concentration between epoetin alpha…
Primary Objective: To investigate the relationship between disease activity and iron deficiency (i.e. absolute and functional ID combined) in children with IBD. Secondary Objectives: 1.To establish the prevalence of iron deficiency (both absolute…
To obtain fresh mononuclear cells from healthy volunteer donors to be used for validation of procedures for the generation of GMP-grade T cell or tolerogenic dendritic cell products for clinical application.
The main objectives of this study are:1. To identify the role of conformational changes of ADAMTS13 on hyperfibrino(geno)lysis in in vitro coagulation tests (primary)2. To identify the role of plasmin on ADAMTS13 conformation on in vitro coagulation…
To evaluate the effects of a tailored invention focused on disease acceptance for patients with haemophilia on prophylaxis.Secondary objectives:* Evaluation of feasibility of collection of preliminary outcomes:o Adherence, measured with the Delphi…