572 results
Main study objectives:* To Identify the incidence, severity and temporal relationships of subjective and objective oral complications related to type of conditioning regimen in HSCT recipients* To determine which oral complications can predict…
The purpose of the study is research. The study investigates to what extent ANF Rho is tolerated in comparison to Neulasta® (representing standard of care treatment) and placebo. A placebo is the same formulation as the study medication without the…
- Assess the incidence of major bleeding and clinically relevant non-major bleeding- Assess the incidence of recurrent venous thromboembolism- Assess the asymptomatic deterioration in the thrombotic burden on repeat imaging- Characterize the…
MRI vessel wall characteristics of peripheral arteries and arterial stiffness in hemophilia patients
The primary objective is to analyze and compare morphological (media- thickness) and functional (stiffness) vessel wall parameters of peripheral arteries between hemophilia patients with an ankle- brachial index >= 1.3 and hemophilia patients…
The study has 3 objectives: 1. Proving that this form of RCA does not increase the risk of bleeding while achieving a degree of anticoagulation of the extracorporeal system that is similar to that when using LMWH. When this study shows that citrate…
The purpose of the study is to investigate the effect on the body of enoxaparin manufactured by the Sponsor (this is called pharmacodynamics) and to compare it with the pharmacodynamic effect of Clexane®. In addition, it will be investigated to what…
The main purpose of the study is to assess immune cell dynamics in Tecfidera-treated MS patients and untreated healthy subjects, and to explore whether differences in immune cell dynamics exist between both populations. The data generated in this…
The primary efficacy objective of the study is:* to evaluate whether rivaroxaban added to ASA is superior to ASA alone in reducingthe risk of major thrombotic vascular events (defined as MI, ischemic stroke, CVdeath, ALI, and major amputation of a…
Primary objective:- To assess the safety of concizumab given as multiple s.c. doses to subjects with haemophilia ASecondary objectives:- To assess pharmacokinetics of concizumab in subjects with haemophilia A after multiple s.c. doses- To assess…
Aim of the study* To determine age-and sex-dependent reference values of the iron regulatory hormone hepcidin.* To determine age-and sex-dependent reference values of newer parameters to determine iron deficiency, such as soluble Transferrin…
To evaluate the efficacy, safety and feasibility of combined immune modulation with rituximab, ITI and MSCs in terms of eradication of FVIII inhibitory activity in hemophilia A patients.
To explore the effects of acute fear on the coagulation system while sitting still.
To determine the safety and efficacy of coversin in the treatment of patients with PNH resistant to eculizumab.
The influence of Annexin A2 SNP (rs17845226) on von Willebrand factor secretion by endothelial cells
The aim of this research is to study the effect of Annexin A2 SNP rs17845226 on vWF secretion by endothelial cells of controls carrying different Annexin A2 SNP rs17845226 genotypes (WT, homozygous, heterozygous). By testing several endothelial cell…
Primary objectiveTo evaluate and compare the single-dose pharmacokinetic of turoctocog alfa pegol from the pivotal process with turoctocog alfa pegol from the commercial process, each given as intravenous administrations of 50 U/kg to patients with…
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
The purpose of Part 1A is to investigate how safe RO7112689 is and how well RO7112689 is tolerated. Part 1A will also investigate how quickly and to what extent RO7112689 is absorbed into, distributed in, and eliminated from the body (this is called…
To measure the effect of lowering or stopping biologicals on various coagulation parameters in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.
To assess whether the inhibitory effect of CK on platelet aggregation can be reversed in vitro.
Primary Objective: To assess whether the current use and dosing in cirrhosis of anticoagulation is as effective in inhibiting ex vivo thrombin generation compared to the treatment of patients with competent liver function