572 results
This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…
In the present ex vivo study we aim to determine whether thromboelastometry parameters, in particular the lysis onset time (LOT), are appropriate to determine and quantify the degree of hyperfibrinolysis. Furthermore, we will study the association…
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
To investigate whether a decrease in portal pressure after placement of a transjugular intrahepatic portosystemic shunt results in a decline in von Willebrand factor plasma levels.
- The primary research objective is to estimate the prognosis of children affected by ICL. - A secondary research objective is to explore the heredity of ICL between first degree family members.
The objective of this study is to investigate whether thrombin generation is effected by different shear rates and different tissue factor concentrations in plasma, platelet rich plasma and whole blood. Thrombin generation in plasma with/without…
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.
The objective of this pilot study is to investigate wether:- Increased Hb levels prior to the operation can prevent blood transfusions preoperative, blood transfusions have a negative effect on the survival of cancer patients- Treatment with…
- To gain insight in dynamics of PTX3, bonemarkers PYD, DPD and zinc during admission for sickle cell painful crisis.- To correlate the above markers with clinical parameters of severity of painful crisis (pain score, the occurrence of…
- Evaluation of mean increase in serum creatinine and the incidence of CIN following CT-PA without prehydration compaired to a short prehydration regime with sodium bicarbonate during one hour.- Furthermore, the risk of developing CIN after CT-PA…
• Evaluation of the incidence of CIN after CT-angiography with a hydration regime during 1 hour with sodium bicarbonate compaired to a hydration regime with saline during 24 hours.• Furthermore the risk for developing CIN after CT-angiography is…
To study the effect of 80 mg aspirin intake at bedtime compared with 80 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.
To measure the effect of intravenous ferric carboxymaltose treatment on exercise tolerance, microvascular perfusion and perioperative hemostasis in patients with mild iron deficiency anemia undergoing arterial vascular surgery.
Evaluation of acute joint damage immediately after a joint bleed in patients with haemophilia, by use of a panel of state-of-the-art biomarkers of cartilage and bone turnover measured in blood and urine. The question that will be addressed is…
We will study the effects of the proteins of the contact activation system in thrombus formation, embolization and degradation in several coagulation assays.
To study whether preoperative transfusion increases or decreases the likelihood of having problems after surgery
To investigate the potential of an interaction between 4 mg/kg sugammadex and aspirin on platelet aggregation using collagen-induced whole blood aggregometry in young healthy male volunteers.
To compare the efficacy of erythropoietin beta administered weekly using an early start approach (Hb * 7.2 mmol/l) with standard starting approach (Hb * 6.2 mmol/l) in subjects with lymphoproliferative malignancy, receiving chemotherapy during a 16-…
We aim to evaluate the use of MRDTI in the diagnosis of acute proximal DVT, comparing the findings with CUS. To evaluate the outcome of patients with positive and negative MRDTI and CUS, clinical outcome after 3 months of follow-up will be measured…
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…