80 results
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
Evaluation of the safety and efficacy of bortezomib combined with cyclophosphamide and dexamethasone for induction and maintenance therapy.
Evaluation of acute joint damage immediately after a joint bleed in patients with haemophilia, by use of a panel of state-of-the-art biomarkers of cartilage and bone turnover measured in blood and urine. The question that will be addressed is…
To compare the efficacy of erythropoietin beta administered weekly using an early start approach (Hb * 7.2 mmol/l) with standard starting approach (Hb * 6.2 mmol/l) in subjects with lymphoproliferative malignancy, receiving chemotherapy during a 16-…
In this study, we will investigate the use of optical spectroscopy in determining neonatal bilirubin and hemoglobin blood levels. The outcome and accuracy of the optical spectroscopy measurements will be compared to the outcome of laboratory blood…
The aim of the project is to investigate the effects of five contrasting air pollution scenarios on respiratory and cardiovascular health of young healthy volunteers.
Evaluate iron metabolism, erythropoiesis and hemoblobin level periooperative in patients treated with postoperative intravenous iron injections compared to controls.
Primary: To determine whether IL-1 inhibition by Canakinumab is efficacious in treatment of Schnitzler syndrome.Secondary:1. To assess the effect of canakinumab on Schnitzler syndrome (clinical signs/symptoms and inflammatory biomarkers C-reactive…
to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls
The primary objective of this study is to assess the efficacy and safety of Genz-112638 compared with Cerezyme after 52 weeks of treatment in patients with Gaucher disease type 1 who have been stabilized with Cerezyme. The secondary objective of…
To demonstrate the accuracy of FLT-PET to be an early response parameter for haematological recovery.
Determine the ADAMTS-13 activity in patients with a history of TTP.
The determination of a panel of markers associated with endothelial cell activation and/or damage in patients with a hematologic malignancy, receiving intensive treatment, or sickle cell disease in relation to the effects of transfusion intervention…
Purpose: Determine the ADAMTS-13 activity in patients with a history of TTP.
To evaluate whether acute stress induced by a byngy jump alters the status of the innate immune system
Main study objectives:* To Identify the incidence, severity and temporal relationships of subjective and objective oral complications related to type of conditioning regimen in HSCT recipients* To determine which oral complications can predict…
Aim of the study* To determine age-and sex-dependent reference values of the iron regulatory hormone hepcidin.* To determine age-and sex-dependent reference values of newer parameters to determine iron deficiency, such as soluble Transferrin…
The rationale for this protocol is to use standardized procedures to obtain PBMCs from adult patients with a diagnosis of a CD19 expressingmalignancy for which a CTL019 treatment protocol is currently enrolling or under IRB/EC review, and to…