15 results
To determine whether pathological changes are visible in brain parenchyma, blood vessels or other intracranial structures on ultra high field MRI in SCD patients in normal anatomical areas on 3.0 Tesla MRI and to determine the nature of these…
Main objective of the current study is to evaluatie clinical, laboratory and genetic risk factors associated with prograssion of neurological damage. The final objective is to make a prognostic model of these risk factors to predict early…
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.
- To gain insight in dynamics of PTX3, bonemarkers PYD, DPD and zinc during admission for sickle cell painful crisis.- To correlate the above markers with clinical parameters of severity of painful crisis (pain score, the occurrence of…
Aim of the study is to answer the following questions:1. Is cerebral autoregulation impaired in SCD compared to historical control groups and published standard values?2. Do patients with a high level of steady state haemolysis have a more impaired…
In this study the cumulative incidence and the clinical and immunogenetic determinants of allo-antibody formation in SCD patients in response to RBC transfusion will be evaluated.
In this study, the genetic risk factors and time dependent risk factors for alloimmunization will be analyzed. Furthermore, the role of the innate and adaptive immune system on allo-antibody formation in SCD patients will be elucidated.
The overall aim of this project is to delineate the role of neutrophil activity and diversity in the pathogenesis of acute (e.g. vaso-occlusive crisis (VOC) and Acute chest syndrome (ACS)) and chronic complications in sickle cell didease and its…
To determine the natural history of sickle cell disease and to identify modifying factors, including: (epi)genetic, biological, pathophysiological, social/ demographic, psychological and therapeutic determinants, which contribute to morbidity and…
Investigating red blood cell deformability changes, during treatment, measured with hyperoxia-hypoxia ektacytometry in sickle cell anemia patients, patients with HbSC disease and patients with HbS-beta-thalassemia.
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
The characterization of the immunophenotypic profile of PBMC subsets in steady state SCD patients. The determination of general T cell function in SCD patients. Both will be used as reference profiles in further research evaluating immune…
The aim of this study is to get more insight in the pathogenesis of (P)SCR by comparing: (1) Red cell characteristics (deformability and point of sickling in hypoxia measured by the Oxygenscan), (2) Angiogenesis by determining several biomarkers of…
To assess what the survival of transfused red blood cells (RBC) is in patients with sickle cell disease and *-thalassemia.
Assessing different modalities of ektacytometry in diagnosing thalassemia and/or iron disorders. Investigating the influence of hemoglobinopathies and iron disorders on red cell membrane deformability in comoparison with healthy controls.