49 results
Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…
1. Determine whether thrombo-elastography (TEG) the occurrence of postoperative blood loss and transfusions can predict after cardiac surgery.2. Determine whether platelet aggregometry (Multiplate and Verify Now) can predict the occurrence of…
The objectives of this study is to determine the recovery and survival of platelet concentrates; in the first phase, a comparison will be made for platelet concentrates in plasma stored for 2-3 days versus those stored for 6-7 days; in the second…
• The primary objective of this study is to assess the long term safety of fostamatinib in subjects with persistent/chronic ITP.• The secondary objectives of this study are to establish the long-term efficacy of fostamatinib in achieving and…
A prospective randomized phase III clinical trial to study the effectiveness of pathogen-reduced platelet concentrates in plasma, stored for up to 7 days, and compare these with untrested platelet concentrates in plasma, stored for up to 7 days. The…
1. To assess tolerability and safety of BAX 826 after a single infusion in previously PTPs with severe hemophilia A.2. To determine the pharmacokinetic (PK) parameters of BAX 826 compared to ADVATE.3. To evaluate the impact of anti- PSA antibodies…
We propose an observational clinical trial in critically ill patients to investigate the effect and duration of platelet transfusion on coagulation, including platelet function and markers of endothelial activation in critically ill patients.
To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.
To test the hypothesis that IVIG treatment diminish the risk of development of chronic disease, we designed a prospective clinical intervention study in children with newly diagnosed ITP.
Determination of non-inferiority of volume-reduced platelet concentrates compared to plasma platelet concentrate in terms of recovery. To assess safety (bleeding and thrombotic complications, and adverse transfusion reactions) and transfusion…
The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
1. To compare the platelet function between healthy controls and patients with ET under both static and dynamic conditions. 2. To study the effects of anagrelide and hydroxyurea on platelet function. 3. To study the intrinsic platelet activation…
To characterise the different platelet activating pathways using the FACS assay and the different steps of primary hemostasis with a perfusion flow model in patients with hereditary thrombocytopathies; Storage Pool Disease (SPD), Glanzmann*s…
To study the effect of different treatment modalities, in newly diagnosed ITP patients, on disease activity, platelet activity, the results of the MAIPA, and the relation between these.
This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…
To study the effect of 80 mg aspirin intake at bedtime compared with 80 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.
Primary:To demonstrate the safety of AMG 531 in severely refractory thrombocytopenic subjects with ITPSecondary:To monitor hematological responses to AMG 531To provide open-label use of AMG 531, and to investigate its utility in severely refractory…
The primary aim of this MAPCAT-study is to investigate whether pharmacokinetics of clopidogrel differ significantly betwen different clinical scenarios. A second aim is to study specifically whether genetic polymorfisms influence these…
The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients