22 results
To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.
-Assess the incidence of major bleeding and clinically relevant non-major bleeding -Assess the incidence of recurrent venous thromboembolism -Characterize the pharmacokinetic/ pharmacodynamic profile of a 30-day treatment with oral rivaroxaban
PART A: To assess the efficacy of BAY 94-9027 in prevention and treatment of bleeding at different infusion schedules.PART B: To assess the safety and efficacy of BAY 94-9027 in the prevention of bleeding during major surgical procedures.
The objective of this study is to collect blood samples of women who participated in the ALIFE trial, to test for several DNA-variations as well as anti β2 glycoprotein antibodies, but also to perform overall coagulation assays, such as clot lysis…
This study aims to collect biochemical evidence for the pro-hemostatic capacity of DDAVP in patients with cirrhosis, in order to proceed towards a more rational clinical use of this drug.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
Bloodloss study after Aortic valve replacement
Impact of Mecc perfusion vs conventional ECCperfusion
Peri-operative Bloodloss after Aortic valve replacement
To understand why statins are able to decrease the risk of developing venous thrombosis, by analyzing whether statins can influence pathways that inhibit coagulation.
To assess the prevalence, severity and impact of arthropathy in patients with moderate or severe VWD and a history of documented DDAVP or clotting factor concentrate treatment for joint bleeds. To compare arthropathy in these patients to age, FVIII…
The main object is to evaluate the validity of a diagnostic screening package for bleeding tendency consisting of point-of-care devices when compared with the gold standard for bleeding tendency diagnosis.Other objects which will be investigated are…
To investigate in a randomized controlled trial, whether giving Cofact pre-operatively can reduce the bloodloss and transfusion requirements during orthotopic liver transplantation. Also we investigate the safety of Cofact in this patient population…
Evaluate whether FVIII/VWF concentrates successfully induce immune tolerance in patients who have already experienced and failed immune tolerance induction with VWF-free FVIII concentrates.
The aim of the present study is therefore to investigate the commonly used LA lidocaine in its ability to attenuate thrombocyte aggregation in vitro.
Is there an increase in markers of trombogenese (platelet activation, d-dimeer, von willebrandfactor, OPG) in elderly users of antipsychotics six to ten days after the start in comparison to the same markers before start of the antipsychotic…
The aim of this study is to investigate if there is a correlation between the clinical phenotype (defined as age of first bleeding) of patients with haemophilia A and the results of the whole clotting assessment (TMETP + T-TAS).The results will…
To investigate the functionality of the hemostatic system in patients at one year after OLT. Specifically, we will investigate the function of primary hemostasis (i.e., blood platelets), secondary hemostasis (i.e, the mechanisms responsible for…
To investigate the in vitro effect of pro- and anticoagulants on the hemostatic capacity of plasma from patients with liver cirrhosis.
Primary :To evaluate the prothrombin time (PT) in healthy volunteers treated with edoxaban alone or preceded by apixaban.Secondary : To assess the effect of edoxaban alone or preceded by apixaban on additional pharmacodynamic (PD) assays: activated…
To assess the Pharmacokinetic and Pharmacodynamic properties of three dosages of Coagulation Factor VIIa (Recombinant) in congenital hemophilia A or B patientsTo assess the safety of three dosages of Coagulation factor VIIa (Recombinant) in…
In the present ex vivo study we aim to determine whether thromboelastometry parameters, in particular the lysis onset time (LOT), are appropriate to determine and quantify the degree of hyperfibrinolysis. Furthermore, we will study the association…