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Blood donation for experimental in vitro research

Sample collection for in vitro research

Profiling bone marrow from kidney transplant recipients

Previous studies have shown that the origin of trained innate immunity lies in the bone marrow and is determined by epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells. In this study, we investigate whether long-term…

Stress-induced immune reprogramming in cardiovascular disease (STRESS-CVD)

To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.

Prospective study to evaluate trained immunity in kidney transplantation

In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…

Promoting Resilience in Youth through Mindfulness mEditation

The aim of this study is to determine if mindfulness-based early intervention reduces internalizing symptoms in help-seeking youth and prevents their development into (serious) psychiatric illnesses. In addition we will examine putative changes in…

Model Informed preciSion doSIng tO iNdividualise and optimize pharmacotherapeutic treatment (MISSION) - Appendix 1: Prospective evaluation of Model informed precision dosing (MIPD) for tacrolimus and mycophenolic acid in paediatric patients with a kidney disease

Overall objective:To improve the existing drug prescribing and treatment monitoring process.Objective appendix 1: To prospectively evaluate the predictive performance of the MIPD strategy for tacrolimus and mycophenolic acid in paediatric patients…