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An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples from adult participants with metastatic Non-Small Cell Lung Cancer (NSCLC) for potential inclusion in the MSD Phase 3 clinical trial (Protocol No MK-1084-004) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit.

To utilize the therascreen KRAS RGQ PCR Kit (KRAS Kit) as a screening test to identify KRAS G12C mutations in newly diagnosed metastatic NSCLC participants and thereby determine eligibility for enrolment into the Phase 3 clinical study (MK-1084-004…

Defeating Fear with Exposure therapy delivered by mental health nurses in primary care for Anxiety Disorders in older adults - a cluster-randomized controlled trial

The primary objective of this study is to evaluate the (cost-)effectiveness of ET for late-life anxiety disorders delivered by trained MHNs in primary care, in terms of anxiety and quality of life, compared to UC. UC is not restricted, and the GP…

Psychoeducation for Older Adults with Autism

The aim of this study on the one hand is to gain insight into: 1) the effects of a PE program for older adults with (suspected) ASD in terms of knowledge and recognition of ASD and traits, a better acceptance of the diagnosis,…

A pilot study of Acceptance and Commitment Therapy (ACT) for adolescents with autism spectrum disorder (ASD)

The goal of the current observational multicenter pilot study is to investigate if an 8-week Acceptance and Commitment group therapy for youth with ASD is an effective intervention to increase adaptive emotion regulation, psychological flexibility…

Enhancing effect of dual interventions versus conventional TMS in the treatment of
depression

rTMS is an intensive but effective treatment that could benefit from further optimization. Cognitive control training (CCT) engages the same underlying neural circuitry as rTMS and has been shown to improve therapeutic response (Koster et al., 2017…

Presepsin pilot study

The objective of this pilot study is to assess whether transportation of the sample via a pneumatic tube system (PTS) has any detrimental effects on the recovery of presepsin levels, when compared to traditional hand-delivery. This research will be…

Clinical Performance Study Plan (CPSP) for the use of GenDx CDx Tedopi for subject enrollment on to the OSE Immunotherapeutics Phase 3 trial (OSE2101C302) of OSE2101 versus docetaxel in HLA-A*02 positive patients with metastatic Non-Small Cell Lung Cancer (NSCLC) and secondary resistance to immune checkpoint inhibitor (ARTEMIA)

This clinical performance study/clinical investigation will evaluate the safety and effectiveness of GenDx CDx Tedopi in identifying HLA-A*02 status in metastatic NSCLC subjects who may be eligible for treatment with OSE2101.

Ultrarapid genomics for the critically ill

We have recently implemented ultrarapid genetic testing using Nanopore long-read genome sequencing (LR-GS) at Erasmus MC to guide treatment and enhance outcomes in urgent care scenarios. In this study, we aim to retrospectively…

TransMind

This mixed-methods pilot study will explore the effects of a group-based MBI on body and emotional awareness in TGD individuals by collecting both quantitative measures and qualitative experiences on an adapted gender-inclusive MBI program.&…

Explore Your Brain - Dyslexia

Through a randomized-controlled trial, we aim to investigate the effect of a growth mindset intervention for children with dyslexia on the effectiveness of their dyslexia treatment. Our primary hypothesis is that children who have received the…