33 results
In patients diagnosed with a hip fracture who also have acute myocardial injury on presentation to hospital, is accelerated surgery superior to standard care for the primary outcome of death at 90 days after randomization?
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…
The main objective of the SOPI study is to select the HRD test that best predicts longest PFS on PARP-i in non-BRCA1/2 EOC patients, in order to adequately select patients that will benefit from a PARP-i. Secondary objectives are: to…
The objective is to improve the understanding of intracochlear electrocochleography for objective measurement of residual hearing. ECochG responses obtained postoperatively in patients with different aetiologies will be evaluated in…
To evaluate the feasibility of remote eCTG monitoring in complicated pregnancies between 32-37 weeks in a Home@Hospital setting. Secondary objectives are to evaluate automated interpretation of remote eCTG monitoring and to assess perinatal and…
The primary objective of the current pilot study will be to assess the feasibility of participant selection methods to identify individuals with cam morphology free of hip OA.Secondary objectives includea) the evaluation of the willingness of…
Identification of the dynamics of hs-cTnI and hs-TnT release during and after anthracycline treatment (doxorubicine in combination with cyclofosfamide) in breast cancer patients in order to determine the optimal sampling time point, most reflective…
The primary objective of the pilot study is to assess the feasibility of a definitive trial to determine the effect of arthroscopic soft tissue stabilization vs. non-surgical treatment on rates of recurrent anterior …
Our aim is to develop JITAIs focused on behavioral activation (BA) for depression in close collaboration with patients and therapists, and to examine their usability, feasibility, and preliminary effectiveness.
The primary aim of the proposed study is to evaluate the effectiveness (1) and cost-effectiveness (2) of a DST for patients with anxiety and/or mood disorders in comparison to UC.The secondary aims are: 3) to identify what works for whom by…
To develop a FOG prediction algorithm under free-living conditions, and to test evaluate the use of the Parkinson's Vibrating socks under the same conditions
The prognostic accuracy of combining these four criteria to predict the later development of personality disorders (with/without psychosocial breakdown) is investigated in a longitudinal study. From this, a selection of items with the strongest…
1. To identify the perceived barriers and facilitators for initiating and maintaining a healthy lifestyle in people with both DM2 and a low SEP. 2. To co-create a digital, personalised CBT lifestyle tool together with end users (people with DM2) to…
The purpose of this clinical study is to evaluate the safety and clinical efficacy of the VDyne System in the treatment of moderate or greater TR.
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…
To assess the impact of a nutritional formulation containing caprylic acid and omega 3 fatty acids on skeletal muscle function recovery from damaging exercise.
Primary Objective: Assess the leakage of FFP2 respirators and surgical masks in human subjects using inhalable aerosols consisting of a solution of fluorescein in water. Secondary Objective(s): (a) Study the variability in total…
The primary objectives of this study are to evaluate the safety and effectiveness of a novel diagnostic approach applying PSA-density and MRI-imaging-based monitoring, as opposed to immediate prostate biopsy, in men with an intermediate risk of…
The main objective of this study is to establish a controlled human infection model for Chikungunya using the VLA1553 vaccine.Primary objectives:- To assess the infection rate induced by a single administration of the VLA1553 vaccine- To assess the…