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Treatment in patients with recurrent infections and IgG Subclass Deficiency, and/or Deficient Anti-Polysaccharide Antibody Response.

The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…

Multicenter randomized clinical trial in Patients with Juvenile Idiopathic Athritis: Safety and efficacy of vaccination with live attenuated Measles, Mumps, Rubella vaccine

The primary goal of the current study is to study the safety of and serological response to the MMR booster vaccination in JIA patients. Based on a retrospective analysis we hypothesize that MMR vaccination does not aggravate JIA disease and that…

Induction and waning of specific immune mechanisms against Bordetella Pertussis after infection.

I. Evaluation of the nature and maintenance of specific cellular immune mechanisms after infection with Bordetella pertussis in different age groups, to identify critical parameters for pertussis re-emergenceII. To relate individual patient*s…

Grip op je dip online (Master your mood online): development and effectiveness

The aim of the project is to further develop and study the effectiveness of the Internet groupcourse Gripop Je Dip Online for young people (16-25 years) with depressive symptoms.Development objective:The eight-session groupcourse will be adapted…

A multi-center, randomized, controlled trial with programmed introduction of Sirolimus-based, Calcineurin inhibitor free immunosuppression in recipients of non-heart-beating donor kidney grafts.

To investigate the safety and efficacy of a programmed introduction of a sirolimus based calcineurin inhibitor free maintenance immunosuppressive regime three months after renal transplantation in recipients of a non-heart-beating donor kidney graft…

On-line: Web-based Cognitive Behavioural Therapy (CBT) for Diabetic Adults with Minor to Moderately Severe Depression. A Randomised Controlled Trial.

This study aims to test the effectiveness and appreciation of a web-based cognitive behavioural therapy (CBT) program for adult diabetic persons with minor to moderately severe depression in a randomized controlled trial.

Effects of a high-fat and a low-fat diet on early biomarkers of metabolic stress in blood and gene expression in the small intestine of healthy subjects

The objective of this study is to compare in healthy subjects the effects of a HF diet (40 En% fat) with those of a LF diet (20 En% fat) on early biomarkers and parameters of metabolic stress in blood and on expression of genes in the small…

Prevention of neutrophil induced extracellular matrix damage following skin exposure to solar simulating radiation (SSR)

To investigate the effect of a sunscreen, a topical antioxidant and a topical corticosteroid on erythema, infiltrating neutrophils and oxidative stress following exposure of the skin to SSR.

Analyses of pathogen and host determinants in hospitalized patients with a laboratory confirmed Staphylococcus aureus infection: The PATHOS Study

Objective: to study host and pathogen determinants of S. aureus infection to identify a putative antigen as target for the development of a prophylactic vaccine against S. aureus.

Cefazolin, 1 gram fits all?

Objective: 1) to assess whether adequate serum and interstitial fluid levels of cefazolin are reached during surgery in obese and non-obese patients, 2) to develop a population pharmacokinetic model for cefazolin which allows the characterization of…

Patients' view on the prevention of preterm birth (Preventing preterm birth in women with a previous preterm birth: identification of obstacles to change)

The aim of this study is to identify factors that can hamper of facilitate the implementation and to use this knowledge to develop an effective implementation strategy.

Prediction of psychosis: a follow-up study.

HypothesisChildren and adolescents with non-psychotic psychiatric disorders represent a vulnerable group high prone for psychotic symptoms. In contrast with normal populations more pronounced symptom and cognitive profiles will be found predicting…

Sexuality and the self: studying gender-, social- and cultural differences in sexual self-concept as an explanation for unplanned pregnancies and abortion in teenagers

Aim of the research is the development and evaluation of an intervention to promote the sexual and reproductive health of adolescents who differ in cultural background. Fundamental idea is that sex education is more effective if the information is…

Desensitization of highly pre-sensitized dialysis patients waiting for kidney transplantation by Rituximab, IVIG-L and rescue Plasmapheresis
THE DRIP STUDY

1. Primary end point is achievement of a negative cross-match test with the donor kidney and transplantability.2. Secondary objectives are patient and graft survival, graft function as assessed by calculated creatinine clearance, proteinuria, the…

Prospective cohort study on the effect of surgical treatment of obstructive sleep apnea syndrome on blood pressure (and other cardiovascular risk factors).

In The Netherlands 2% of women and 4% of men suffer from Obstructive Sleep Apnea Syndrome (OSAS). NCPAP, the gold standard therapy for moderate to severe OSAS has been shown to reduce blood pressure in OSAS. NCPAP therapy is however hampered by…

Effects of fall training on fall severity in healthy elderly subjects

The purpose of this pilot study is to evaluate the fall training in older individuals by reduction of hip impact forces. Furthermore, to determine if older individuals are able to perform these fall techniques after training, fall performance is…

The risk of colorectal adenomas in patients with duodenal adenomas.

Study the risk of colorectal adenomas in patients detected with duodenal adenomas.

Phase I and IIa trial for assessment of safety, immunogenicity and efficacy against sporozoite challenge of the candidate malaria vaccine PfLSA-3-rec.

To screen two different formulations of the recombinant malaria vaccine PfLSA-3-rec, one adjuvated with aluminium hydroxide and one with Montanide Isa 720, by assessing the safety and immunogenicity (phase I) profile of each formulation in humans,…

Safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens in patients with rheumatoid arthritis treated with anti TNF-* antibodies (adalimumab) or anti B cell therapy (Rituximab).

To assess the effect of adalimumab and rituximab on the safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens.

Muscle disbalance and proximal deformaties of the femur in children with myelomeningocele

The general accepted Hueter-Volkmann law describes the inverse relation between compressive forces on the physis and the rate of physeal growth. So compression decreases and tension increases longitudinal growth. The observed deformities in patients…