2345 results
Primary objective:- To study the impact of community acquired pneumonia in children on persistent symptoms and quality of life, from admission in hospital until one year after discharge.Secondary objectives:To investigate/assess:- The association…
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…
Primary study objective:To impartially identify the focus of breathing (thoracic or abdominal) using respiratory inductance plethysmography for children aged 8 to 18 with dysfunctional breathingSecondary objectives:• To investigate the effects of…
The aim of this project is to test the hypothesis that symptom-free days (SFDs) of children with preschool wheezing can be increased using Luchtbrug Junior, while reducing regular outpatient visits by 50%.
The key objective of this study is to determine the clinical significance of using MRI scans as a diagnostic tool to assess velopharyngeal insufficiency in cleft palate patients.
To assess the long-term clinical outcomes using Patient-reported Outcome Measures (PROMS), physical examination and radiological sequelae of acute septic arthritis in children.
Primary 1) Establish whether HTx induces a trained immunity phenotype of circulating mono-cytes in pediatric and adult HTx patients, and compared to healthy controls.2) Investigate whether trained immunity phenotypes in pediatric and adult HTx…
Primary Objective:- To investigate the effectiveness of the combined treatment *Speaking at school, a matter of doing* with the addition of the VR homework exercises. Secondary Objectives:- To identify factors that predict adherence to the VR…
Is biofeedback gait training on the Gait Real Time Interactive Lab (GRAIL) feasible in children with mild recurrent clubfoot over 4 years of age? And to explore the effect in achieving clinically relevant immediate and short-term improvements in…
The aim of this project is to investigate a parent-mediated treatment method targeting sensory processing difficulties thereby improving the emotion regulation difficulties and quality of life of the child and its family.
To investigate copeptin levels in pediatric polyuric tubulopathies such as Nephrogenic Diabetes Insipidus (NDI), Renal Fanconi syndrome and Bartter syndrome to use it as biomarker for the volume state of these patients.
The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…
We aim to define the growth trajectory of clonal hematopoësis after allogeneic transplantation, and identify potential modulating factors.
1. Primary objective:The primary aim of this study is to investigate the predictive value of OCT parameters at diagnosis for long-term (4-5 years after diagnosis) visual impairment (visual acuity, visual field) in children with a primary brain tumor…
to investigate the role of regulatory T cells in response to heat shock proteins in muscle and peripheral blood of patients with juvenile dermatomyositis. To identify patterns in T-cell responses and cytokineprofiles, in relation with clinical…
The current study describes the Antisocial High-Risk Cohort (i.e., WP3, a sub-project) of the larger Growing Up Together in Society Project (see appendix A), which has the aim to predict and understand behaviour that negatively affects society:…
The aim of this project is to unravel whether BPD after the neonatal period is a chronic inflammatory disease, and if markers of inflammation and/or oxidative stress are related to pulmonary morbidity in patients with BPD. Based on these findings,…
Primary Objective: - Evaluate changes in immune response during oral immunotherapy with either peanut or baked milk in children with a mild peanut or cow*s milk allergySecondary Objective: - Compare the immunological changes at baseline and over…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
In this study, we are looking at the effectiveness of following phase 3, the maintenance phase, of the Crohn's Disease Exclusion Diet (CDED) compared to normal diet (with or without standard maintenance treatment) in children and adults with…