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*Multi-Site RCT of Group Schema Therapy for Borderline Personality Disorder*

Our long-range goal is to develop a comprehensive, clinically and cost effective treatment for BPD that produces both symptom remission and functional recovery. We aim to determine the role that group ST can have in the comprehensive treatment of…

Cervical radicular pain: A randomised controlled trial comparing percutaneous plasma discectomy and anterior cervical discectomy.

The aim of this study is to compare the effects of anterior cervical discectomy versus percutaneous plasma discectomy on pain, on global perceived effect, functional status and health-related quality of life in a group of patients with cervical…

Clinical effectiveness of standard versus pathogen-reduced buffy coat-derived platelet concentrates in plasma in hemato-oncological patients;Pathogen Reduction Evaluation & Predictive Analytical Rating Score (The PREPAReS Study)

A prospective randomized phase III clinical trial to study the effectiveness of pathogen-reduced platelet concentrates in plasma, stored for up to 7 days, and compare these with untrested platelet concentrates in plasma, stored for up to 7 days. The…

A combined diagnostic-therapeutic strategy to optimize management of patients with previously unrecognized heart failure in primary care

To determine the effect of a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized or unestablished heart failure in primary care as compared to care as usual.

A single blind, randomized, cross-over placebo controlled dose finding study to investigate the pharmacokinetic profile of 3 doses of sublingual testosterone solution and their effect on physiological and subjective arousal in healthy, sexually functional premenopausal women.

Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…

The use of Fibrin sealant In total knee Replacement Surgery Trial. A prospective randomised multicentre study.

Is the application of CryoSeal (CS) in primary total knee replacement surgery beneficial for the patient with respect to a faster track and improved postoperative rehabilitation. The beneficial effect may be due to quicker functional knee…

Optimal Sensing in Atrial Tachyarrhythmia's Study

Verification of number of mode switches, Verification of undersensing of AFor other ATAs. Incidence of mode switches due to FFRW oversensing using Accent pacemaker in the most sensitive sensing setting(s)using the Optisense vrs Tendril lead

Mesh versus patch for hernia epigastrica and umbilical repair.
A multicenter patient-blinded randomized trial.

Primary obejective is the evaluation a ventral patch is associtaed with less complications than a conventional mesh for epigastric and umbilical hernias. Complications are defined as unexpected events necessitating a treatment within the period of…

A trial based economic evaluation of Kopstoring: A study on the costs and effects of an online prevention program for children of 16 to 25 years old of parents with mental or substance use disorders.

Main question: p. 12 of proposalIs the online psycho-educative prevention program Kopstoring a (cost) effective program for children of parents with mental or substance use disorders to reduce their symptoms (primarily reduction of internalising and…

DUrable Polymer-based STent CHallenge of Promus ElemEnt versus ReSolute Integrity (DUTCH PEERS): Randomized Multicenter Trial in All-Comers Population Treated Within
Eastern NeThErlands-2 (TWENTE-2)

Primary research questions To investigate whether the outcome after the randomized implantation of the Resolute Integrity® versus Promus Element® drug-eluting stent are similar, as assessed in a non-inferiority setting by comparing target-vessel…

Early intervention for speech sound disorder in very preterm or very low birth weight children: a randomized controlled trial.

The primary objective of this study is to examine the effectiveness of a short, highly structured parent based speech intervention programme on speech development in VP/VLBW children with speech sound disorder (SSD) at 2 years of age.

Multi Center Clinical trial of endovascular treatment of acute ischemic stroke in the Netherlands.

The primary objective of this study is to estimate the effect of endovascular treatment on overall functional outcome after acute ischemic stroke of less than six hour duration, in patients with a symptomatic anterior circulation IAO. The secondary…

A Phase 2 , Randomized , Single - Blind , Controlled , Comparative Efficacy and Safety Study of Topical Fibrocaps * and Gelatin Sponge in Surgical hemostasis in the Netherlands

1. To characterize the efficacy of topical Fibrocaps plus gelatin sponge, as compared to gelatin sponge alone, in surgical subjects when control of mild to moderate bleeding by standard surgical techniques is ineffective and/or impractical2. To…

Evaluation of an improved self-lavaging device, the Delphi® Screener

This study is to answer two questions. First the acceptability and ease of use of the modified version of he Delphi Screener in general and in different body positions. Second the confirmation of a sufficient yield of cervicovaginal cells by self…

EXIST: Physical exercise to improve fitness and combat fatigue in patients with Multiple Myeloma or (non-) Hodgkin*s lymphoma after high dose chemotherapy and autologous stem cell transplantation.

(1) To evaluate the effectiveness of an individualized exercise program in comparison to standard care with respect to fatigue, physical fitness and health-related quality of life in patients with hematologic malignancies who have undergone HDC and…

Properties of dietary fiber and energy intake: An intervention to study the effect of physicochemical properties of dietary fiber on energy intake and underlying mechanisms

To study the effect of pectin in 5 different physicochemical states on ad libitum energy intake and possible underlying mechanisms; i.e. gastrointestinal hormones, gastric emptying rate, feelings of satiety and the method of fiber supplementation.

Alternative APAP Method for Non-invasive Positive Airway Pressure Therapy in OSAHS patients.
Amendment: Mallampati score as a predictor for effective Positive Airway Pressure

1. To investigate whether an adjusted mode of APAP can improve patients adherence in comparison to fixed CPAP in present-day PAP therapy of OSAHS patients.2. To investigate the agreement between the parameters of the CPAP devices and the polygraphy…

Feasibility Of continuous non-invasive blood pressure measurement in cardiac Resynchronization ThErapy

To demonstrate that CNBP can be used for CRT device settings adjustment aimed atoptimization of clinical status of chronic HF patients

A single-blind, double dummy, randomized, multi-dose, two sequence, crossover, study to investigate the effects of Renin Inhibitor (aliskiren 300 mg) on Albuminuria in nondiabetic nephropathy patients treated with ramipril 10 mg and Volume intervention (CSPP100A2260, ARIA study)

Primary: To investigate the effects of 300 mg aliskiren on albuminuria in patients with non-diabeticnephropathy treated with ramipril 10 mg and volume intervention.Secundary: Effects of ramipril and ramipril plus aliskiren. Effects on RAAS…

Single-Center, Randomized Single-Blind Placebo-Controlled Five-Arm Parallel Group Study to Assess Efficacy of a Single Dose of TBS-2 Intranasal Gel at Four Time Points Post-Dose using Vibrotactile Stimulation combined with Visual Sexual Stimulation in Female Subjects with Primary and Secondary Anorgasmia

This clinical trial is being performed to evaluate the efficacy of a single dose of TBS-2 on the occurence of orgasm. This study will explore the effect of TBS-2 on inducing an orgasm following sexual stimuli in anorgasmic female subjects at four…