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Train the sedentary brain: move smart to reduce the risk of dementia;Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relation

Main objectives are to investigate the cognitive effects of alternating endurance-strength training in APOEe4 carriers and non-carriers in early stage dementia and to identify a dose-response relationship of the cognitive effects of exercise.…

*In house* Pre-implantation Oxygenated Hypothermic Machine Perfusion Reconditioning after Cold Storage versus Cold Storage alone in ECD Kidneys from Brain Dead Donors

Objective of this study is to compare 1-year garft survival after hypothemic machine perfusion with oxygentaed perfusion solution versus static cold storage of extended criteria kidneys from DBD donors.

The effectiveness of CPAP-therapy on recurrence of atrial fibrillation after cardioversion in patients with central sleepapnea

The objective of this study is evaluation of the effectiveness of CPAP-therapy on recurrence of atrial fibrillation after cardioversion in patients with central sleepapnea and in case of proven effectiveness possibly using CPAP-therapy as standard…

Continuation of Metformin during surgery in patients with diabetes mellitus type 2

The objective of the study is to investigate the glucose lowering potential and safety of continuation of Metformin during non-cardiac surgery, compared to discontinuation of Metformin 24 hours before surgery.

Long term effectiveness and cost-effectiveness of an elimination diet trajectory compared to care as usual in the treatment of Attention Deficit/ Hyperactivity Disorder in children aged 5 to 12 year

Determining the long-term (18 months) effectiveness and cost-effectiveness of an elimination diet (ED) as the first addition to care as usual (CAU) in comparison to providing CAU only in children with ADHD (5-12 years). Hypotheses: Long-term…

A Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 (a Low Volume Bowel Cleansing Solution) versus a Sodium Picosulfate and Magnesium Salt (SP+MS) Solution Using a Day Before-Only Dosing Regimen in Adults

Primary Objectives: To evaluate the overall bowel cleansing efficacy and the *Excellent plus Good* cleansing rate in the colon ascendens of a 1-day day before-only split-dosing regimen with NER1006 compared to a 1-day day before-only split-dosing…

"The Shrink Study: shrink factor of resected tumour mucosa in patients with oral squamous cell carcinoma"

Investigate whether different resection modalities such as MO or TL cause a different amount of shrinkage in the mucosal margins of resected OSCCs.

Motor imagery training in children with Developmental Coordination Disorder

Studying the effect of two intervention programs (1. Motor Imagery Training, 2. Cognitive Orientation to Daily Occupational Performance (CO-OP)) on the motor abilities, motor imagery and motor planning capacities in children with Developmental…

Ultrasound Navigation Guided Improvement of High Grade Glioma Resection and Quality of Life: a phase III Randomized Controlled Trial.

Primary ObjectiveTo investigate whether ultrasound guided tumor resection succeeds gross total resection significantly more frequently, when compared with the conventional non-ultrasound guided tumor resection.Secondary Objective(s)To investigate…

RAP and BEAT Clinical Trial (Radial Artery Patency and Bleeding,
Effectiveness, Adverse evenT Trial)

The objective of this study is to demonstrate the safety and efficacy of thenew 6Fr sheath (Glidesheath slender 6Fr; GSS 6Fr) compared with thecontemporary 5Fr sheath (standard of care 5Fr; SOC 5Fr) both from Terumo;Tokyo, Japan.

Train the sedentary brain: move smart.
The effects of an interactive cycling training on cognitive functioning in older persons with early stage dementia.

Our aim is to investigate the cognitive effects of an interactive cycling training in early stage dementia patients (in comparison to an aerobic cycling training and a control group).In addition we will investigate whether the effects of training…

A Multi-Centre Randomized Trial Comparing Total Hip Arthroplasty and
Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Patients with
Displaced Femoral Neck Fractures

The primary objective is to assess the impact of total hip arthroplasty versus hemi-arthroplasty on rates of secondary procedures at 2 years in individuals with displaced femoral neck fractures.

An RCT on the effectiveness of a serious game for patient with a developmental disorder with anxiety symptoms using cognitive bias modification.

The objective of this study is to examine wheter a serious game using cognitive bias modification is effective on anxiety symptoms regarding patients with an autism spectrum disorder.

Sleeve Gastrectomy and the Influence of Concomitant Hiatal Hernia Repair

To define the exact effect of LSG with and without concomitant HH repair on the prevalence of GERD and GERD-related symptoms in obese patients who are intraoperatively diagnosed with a small HH. Furthermore, to examine the effect of LSG on the…

First web-based Dual Disorder Treatment Trial among Problematic Alcohol Users with Moderate Depression Symptoms

The objective will be to test the effectiveness of a web-based intervention aiming to reduce alcohol consumption and depression symptoms combined, a web-based self-help intervention focusing on problematic alcohol use only, and a waiting list…

Does monitored discontinuation of inhaled corticosteroids (ICS) for primary care COPD patients without a clear indication for ICS according to current guidelines results in a reduction of ICS use without adverse health effects.

The objective of the study is to investigate whether discontinuation of inhaled corticosteroids (ICS) for patients without a clear indication for ICS according to current guidelines results in a reduction of ICS use without adverse health effects…

Dance for Health: The effect of a dance program on patients with Multiple Sclerosis

The aim of the current pilotstudy is to investigate the effect of a standardized dance program (provided by the foundation Dance for Health) in MS patients. We will specifically investigate the effect of the dance program on the hippocampus and (…

Discontinuation versus continuation of antiarrhythmic drugs prior to pulmonary vein isolation for atrial fibrillation and influence on dormant conduction with adenosine; a randomised controlled trial.

Comparing incidence of dormant conduction after adenosine challenge and initial succesfull PVI in a strategy of cessation of antiarrhythmic drugs compared with continuation prior to PVI.

Treatment of ADHD with Care as usual versus an Elimination diet:
An exploratory investigation on the biological mechanisms underlying the effects of an elimination diet treatment
in ADHD

The main aim of the TRACE-BIOME study is to characterize the role of biomarkers related to the microbiome-gut-brain pathways in the effect of an ED as a treatment for ADHD.

Postlaparoscopic reduction of pain by combining intraperitoneal normal saline and the pulmonary recruitment maneuver

A promising strategy to reduce postlaparoscopic shoulder pain and abdominal pain is the pulmonary recruitment maneuver. By using manual pulmonary inflations, the intraperitoneal pressure increases and removal of residual carbon dioxide will be…