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Exploratory research into the effect of temporarily withdrawal of PPIs (Proton Pump Inhibitor) use, to reduce the stomach wall uptake of 99mTc-Sestamibi in a myocardial perfusion imaging

4.1 The main questionWhat is the effect of temporarily stopping PPI use on the stomach wall uptake of Tc99m Sestamibi with a myocardial perfusion?4.2 Sub-questions:- What is the relative maagwanduptake a myocardial perfusion Tc99m Sestamibi with…

A randomised, subject-masked evaluation of introcular lens stability after implantation of two different lens models: FEMTIS-study

Primary Objective: The primary objective of this study is to compare postoperative decentration of the FEMTIS-IOL versus a standard monofocal IOL (Acrysof monofocal IOL)Secondary Objective(s): The secondary objectives of this study are to compare:-…

REDUCE LAP-HF Dutch RANDOMIZED TRIAL I:
A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure

The primary objective of this randomized controlled clinical study is to evaluate the peri-procedural safety and potential effectiveness (mechanistic effect) of implanting the IASD System II in heart failure patients with an LV ejection fraction…

The effect of duration of nonabsorbable nasal packing (merocel) soaked with oxytetracycline and hydrocortisone (terrracortril) in the post-operative management of functional endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) on healing of the sinus cavity

The primary objective is to assess whether a 10-14 day Merocel with TC packing of the sinus is better than a one day Merocel with TC packing in the improvement of clinical and sinus parameters in patients with symmetrical CRSwNP following FESS. The…

Internet-based vestibular rehabilitation for older dizzy adults: does it work? A single blind, three arm, randomised controlled trial in general practice

In this study we want to investigate the clinical and cost-effectiveness of internet-based VR, with and without physiotherapeutic support, for older dizzy patients in general practice in comparison with usual care. Furthermore, we want to identify…

The effectiveness of deep versus moderate neuromuscular blockade
during laparoscopic donor nephrectomy in enhancing postoperative recovery.

To establish the relationship between the use of deep neuromuscular blockade (NMB) during laparoscopic donor nephrectomy (LDN) -with standard pressure pneumoperitoneum- and the early quality of recovery.

NASIC: Neural Activation of Social Influences and Colour

The study aims to extend current insights into the effectiveness of nudging by examining neural correlates in two specific areas important for choice architecture; the role of social influences, and the role of colour cues in product evaluation and…

Cognitive behavioral therapy for Misophonia, RCT

To evaluate the effect of the CBT groep treatment for misophonia.

Adherence monitoring of use of custom-made orthopaedic shoes

Objective: To evaluate the adherence of patient*s use of OS.

A Placebo- and Active-Controlled Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Subjects With Major Depressive Disorder

Primary ObjectiveTo evaluate the effect of a single 84-mg dose of intranasal esketamine compared to placebo, on next day driving performance and repeated administration of 84 mg intranasal esketamine on same-day driving performance as assessed by…

The effect of intravenous lactate administration on brain lactate concentrations and pH during euglycemia and hypoglycemia in patients with type 1 diabetes with and without impaired awareness of hypoglycemia

This project consists of two related studies. The objective of part 1 is to investigate the effect of elevated plasma lactate levels that are sufficient to impair awareness of hypoglycemia on brain lactate concentrations during euglycemia and…

Free-hand versus navigation guided percutaneous liver tumor ablation

The objective of the study is to compare free-hand needle placement with navigation guided needle placement.

Tactile stimulation to improve spontaneous breathing in neonatal resuscitation

The objective of this study is to compare the direct effect of repetitive tactile stimulation versus standard stimulation on the respiratory effort of preterm infants during stabilisation at birth. The most ideal comparison would be to compare…

TePA-study (Tertiary Prevention of morbus Asherman-study);Evaluation of placement of hyaluronic acid (hyalobarier ® Gel Endo) and placement of a intrauterine device without cu or hormones to maintain separation of the cavity and mechanically to prevent spontaneous recurrence of adhesions.

Does the installation hyaluronic acid (hyalobarier ® Gel Endo), in patients with M. Asherman reduces or prevents the incidence and severity (ESGE score/classification) of spontaneous recurrence of adhesion better then the IUD without Cu or hormones…

Yoga for young women with depression: a randomized controlled trial

To examine whether adding yoga-based therapy (YBT) to treatment as usual (TAU) for young women with MDD leads to (1) greater reductions in symptoms and (2) greater cost-effectiveness in that the economic benefits of adding YBT to TAU outweigh the…

Clinical, microbiological and radiographical evaluation of implant surface decontamination using air polishing in the surgical treatment of peri-implantitis; a randomized controlled study

The primary objective of this randomized controlled trial is to compare the clinical effect of decontamination of the implant surface during the surgical treatment of peri-implantitis using air polishing or hand instruments. The secondary objective…

Comparison of laparoscopic procedures with and without the aid the AutoLap system - a Robotic Camera Holder

The objective of this study is to evaluate the ability to reduce the number of OR personnel required while performing the following procedures: colon resections (right hemicolectomy, left hemicolectomy/sigmoid resection), anti-reflux/hiatal hernia…

Reported psychotic-like experiences in adolescence in general outpatient clinics and the determination of a cut-off point at the Prodromal questionnaire.

Primary Objective: The aim of this study is to determine a cut-off score at the PQ-16 with the CAARMS for better detection of adolescents 12-18 years at risk. Secondary Objective(s): To study the course of UHR in adolescents 12-18 years over a one…

The Goal dIrected perFusion Trial, a multi-center, prospective, randomized, controlled study.

The present study is designed to verify the hypothesis that a strategy based on a goal-directed perfusion, aimed to avoid a nadir DO2 below the critical threshold, is effective in limiting the postoperative AKI rate.

TApering strategies in Rheumatoid Arthritis remission induced by anti-TNF&classic DMARDs. Should we taper the classic DMARD or anti-TNF first?

Our main aim is to evaluate the effectiveness and cost-effectiveness of two tapering strategies:(i)DMARD tapering and (ii)anti-TNF tapering in RA patients with DMARD&anti-TNF(etanercept, adalimumab, certolizumab or golimumab) induced…