2921 results
To characterize the single-dose pharmacokinetic (PK) of RPV after SC administration of RPV LA suspensions with different doses and/or different particle size (PS) to support further dose and formulation selection, in healthy adult participants.To…
To assess the effects of additional education in combination with more frequent follow up and patient reminders on adherence to treatment in adult EoE patients.
The primary objective is to influence amygdala and ventral striatum neuronal activity, thereby changing their influence on consequent approach/avoidance decisions, as indicated with left or right button presses.
The objective of this study is to accurately assess and compare migration, kinematics, gait analysis, prosthesis placement and patient reported outcomes of two TKR prostheses: the fixed bearing, cemented NexGen LPS, a proven design with an excellent…
To compare the effect of two target ranges (91%-95% and 92%-96%) while on automated oxygen control on the time spent under the target range in preterm infants.
The main objective is to evaluate the effectiveness of three sessions of EMDR FF (targeting negative FF imagery related to youth*s most feared social situations) in treating social anxiety (lowering anxiety and avoidance related to those feared…
Primary Objective: - To determine and compare physical performance in patients with HNC with and without an exercise intervention.Secondary Objective(s): - To determine and compare muscle strength in patients with HNC with and without an exercise…
The primary objective is to compare the Vanguard XP with a CR TKA in terms of kinematics during functional tests using 3D fluoroscopy. The secondary objective is to compare both TKAs in terms of 3D migration of the prosthesis up until 2 years post-…
We will compare the AMPD model to the traditional (Section II) PD model with regard to patients* and clinicians* experience of the clinical utility of both models. As the AMPD model was designed to improve clinical utility, we expect that both…
The high morbidity rate of the perineal wound has resulted in a continuing discussion on how to close the perineal defect after APR. Our research group recently published the BIOPEX-study (NL42094.018.12), in which 104 patients were randomized…
In this study we will compare the (cost)- effectiveness of psychodynamic group therapy (PG) with schema-focused group therapy (SFGT) and group schema therapy (GST). The group formats differ both in amount of sessions (resp. 80, 60 and 30 sessions)…
This study has been transitioned to CTIS with ID 2025-520513-30-00 check the CTIS register for the current data. We aim to optimize the treatment of rheumatoid arthritis patients using concentration measurements. By doing this we hope to reduce the…
In this study we will assess the (cost)effectiveness of a transmural integrated care programme supporting return to daily activities (including work)after knee arthroplasty compared to usual care. We hypothesize our transmural integrated care…
The primary objective of the VertiGO! trial is to assess the feasibility of restoring vestibular function by making use of prolonged VI stimulation. This will be done using a combined VI and CI device: The CVI. To achieve this objective, patients…
The aim of the proposed study is to investigate the effects of antipsychotic medication on total brain volume and specific brain structures known to be affected in schizophrenia, such as hippocampus, thalamus, caudate, parietal and prefrontal cortex…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more…
The objective of this prospective randomized controlled trial is to compare the outcomes of arthroscopic primary repair of proximal ACL tears with the current gold standard of ACL reconstruction.
The primary objective of this study is to compare the migration rates of the two fixation techniques (bony bed vs. subperiosteal pocket), and assess the feasibility of the techniques, thereby assuring the stability of the implant with the least…
The aim of the study is to determine the accuracy of pedicle screw placement when using the iNav navigation tool compared with the established computertomography based navigation.
In the current study we will attempt to evaluate if the diet, termed the UC Diet (UCD), can improve outcomes when administered with a 5ASA regimen to pediatric patients with mild-moderate UC, through a single blinded multinational RCT.