358 results
This study will be focused on the executive functioning of PD patients and the associations between effort, motor symptoms, depression and the executive functioning of PD patients. By investigating to what extent executive dysfunctions in PD are…
Our objective is to study the changes in cytokine levels in dermal interstitial fluid (ISF) obtained by a minimally invasive technique after single and repeated sodium lauryl sulphate (SLS) exposure compared to untreated skin. The study will give…
To elucidate the molecular basis of skin disease.
The purpose of the present study is to clarify the assumed role of fear in women with superficial dyspareunia. The hypothesis will be tested that aversive conditioning in women with dyspareunia and control women will lead to diminished sexual…
Prevalence of cardiovascular disease and their risk factors in patients with ankylosing spondylitis.
This research must answer the following questions: (1) what is the prevalence of CVD in AS patients?(2) what is the incidence of CVD in patients with AS? (3) which risk factors contribute to the development of CVD in AS? (4) to which extent AS…
Several Parkinson patients who live in the same small rural region with a small population (only 70 inhabitants) reported a remarkable prevalence of parkinsons disease (of about 10 patients) in their villag. The expected prevalence of parkinsons…
The aim of the study is to describe the incidence and characteristics of CRPS in the Dutch population. Also will be investigated which factor are associated with the ocurrence of the disease.
The primary aim is to study the effect of treatment of severe AD patients with Myfortic on DNA-repair after irradiation with UVB.A secondary aim is to study the effect of treatment of severe AD patients on atopic status, measured as total IgE and…
To determine the cardiovascular changes in response to orthostatic stress in women with a vascular complicated obstetric history or recurrent miscarriage.
We propose that variation in genes involved in the regulation of motivational behaviour and satiety plays a major role in the development of obesity. We aim to identify these genes using family-based association and linkage analysis in a large…
The present study aims to bridge the gap in knowledge between the risk factors for CD and the developmental pathways to pyschopathy, antisocial personality disorder, and antisocial behaviour. The central question is whether antisocial and…
To gain knowledge about the etiology of emotional changes after bilateral STN stimulation. And also to find out that the research design, where neuropsychological and psysiological aspects are combined, is useful in studying outcomes of STN…
Measures of cerebral perfusion and cerebral metabolism will be compared between patients with different disease courses of MS and healthy controls.Hereby we wish to answer the following questions:- Are cerebral energymetabolism and cerebral…
Aim of this study is to compare the effects of mannitol and HS in equimolar concentrations on cerebral blood flow, cerebral oxygenation, metabolism and inflammation in patients with severe TBI.
The aim of study is to find an answer on the question: What is the role of pain-related fear in the level of disability in patients with CRPS-I?
The overall aim of this prospective study is identifying early markers for Autistic Spectrum Disorders by following the developmental track of visual perception in normal and abnormal development, eventually leading to a basis for effective…
Do patients, suffering from schizophrenia, who have (clinically) a flattening of affect, also have abnormalities in pain perception and expression ( i.e. a higher threshold for pain perception and tolerance).
The objective of this study is to assess the association of genetic polymorphisms known to be involved in coeliac disease with specific clinical phenotypes in coeliac disease.
1. To evaluate the diagnostic value of the short form QST protocol and skin biopsy in ISFN, and to evaluate the diagnostic value of the small fibre neuropathy screening list (developed by Hoitsma et al) in patients with other causes of SFN than…
- Identify key factors of the cardiac transcriptome in patients with cardiac malformations- Identify the transcriptional regulatory interactions underlying the cardiac transcriptome- Bioinformatically map and analyse the cardiac regulatory network…