31 results
To assess the post-operative quality of recovery after robot-assisted as compared to open extended lateral pancreaticojejunostomy.
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
To establish whether the decrease in pulmonary function as a result of wearing a neoprene suit is caused by restriction or obstruction, and which effect is has on pulmonary volumes.
This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden UniversityMedical Centre. If proven successful, home monitoring…
The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…
The primary objective is to examine the effect of twelve weeks supplementing daily one AstaPure® Oleoresin capsule on trans epidermal water loss (TEWL) in postmenopausal women. The secondary objectives are to investigate the effects on other skin,…
Primary Objective: Compare visual acuity between adults born prematurely and adults of general population born at full term.Secondary Objective(s): o Compare other anatomical and functional ocular outcomes (retina, macula thickness, refraction,…
To acquire metabolic health data from three dietary challenge meals for the development of an algorithm for personalised dietary advice, and subsequently test the effectiveness of this personalised dietary advice compared to a general healthy diet…
The objective of the Next Generation ImmunoDermatology project (funding NWO, program NWA-ORC) is to deep profile immune-mediated inflammatory diseases for the identification of biomarkers that can identify different disease endotypes that can…
The primary objective is to evaluate the effectiveness of dietary nitrate in reducing muscle atrophy induced by bedrest. Secondary objectives include assessing its impact on insulin resistance, muscle strength, and cardiovascular function.…
Our project aims to investigate cognitive and linguistic deficits in people with SCD, focusing on working memory impairments, deficits of lexical access, and deficits brought on by syntactic complexity. We will integrate clinical linguistic findings…
Primary Objective: to assess brain kinetics of glutamate, GABA and dopamine and the associated functional connectivity of the mesocorticolimbic circuit during the absorption and elimination phase of JWH-018, as compared to the control condition.…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…
To assess the feasibility of the Virtual Ward in six pre-defined sub-cohorts of non-elective hospitalized patients within the current Dutch healthcar
Primary Objective: To explore the computations which occur in the brain which occur in visual disorders and determine how these differ from healthy controls. Specifically, we expect that the overall sensitivity (area under the curve) which reflects…
The current trial aims to assess and validate atrial fibrillation detection and monitoring by the Corsano CardioWatch 287-2 in a remote setting across multiple international centres. By: a) To compare episodes of atrial fibrillation across 30-second…
The main aim of the study is to compare the optimal protein intake of a protein with a high quality (milk) to the optimal protein intake of a protein with a low quality (wheat) in healthy older adults using the indicator amino acid oxidation (IAAO)…
This study aims to be the first to visualise changes in both clitoris and pelvic floor musculature following testosterone administration and to explore how these changes relate to sexual function. The primary objective of this observational study is…
Primary Objective: The central focus of the 7T study is to investigate the influence of sleep and its various stages, particularly slow wave sleep, on CSF mobility within perivascular spaces.The primary aim of the 3T experiment is to explore the…