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The HEADS-Up Trial: Sleeping in a head-up tilt position to treat orthostatic hypotension, supine hypertension and nocturia in Parkinson's disease

To assess the efficacy and tolerability of HUTS with different angles, leading to optimal implementation strategies of HUTS to alleviate the impact of orthostatic hypotension and supine hypertension in PD

The Neural Basis and Predictors of Wellbeing during the transition from Adolescence to Adulthood

The aim of the study is two-fold: (i) to test the neural basis of domain-specific aspects of wellbeing among adolescents and adults, and (ii) to examine how individual differences in neural emotional reactivity (based on previously acquired data)…

MRSA decolonization in complicated carriage - cluster randomized trial

To determine the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership.

the role of risk factors on the host-pathogen interactions in melioidosis

This study aims to delineate the alterations in leukocyte function during ex-vivo host-pathogen interactions. These data will be correlated with several factors such as coexisting comorbidities (e.g. diabetes) and functional defects analyzed using…

An open-label, mass balance study of 14C-JNJ-40411813 administered as a single oral dose in healthy male participants

The aim of this study is to investigate how quickly and to what extent JNJ-40411813 is absorbed, transported, and eliminated from the body. For this study, JNJ-40411813 is radioactively labelled with carbon-14 (14C). In this way JNJ-40411813 can be…

Fully Automated glycemic control with ultrarapid insulin in a bihormonal closed loop System in patients with Type 1 diabetes.

The main objective is to determine the efficacy of Lyumjev in the Inreda AP system. Secondary objectives are: to assess safety, differences in pharmacodynamics and differences in AP-related outcome measures.

Exploring Metabolic Maturation in the Extremely Preterm Brain at Term Equivalent Age: EMMA study.

We will combine four 7 Tesla MRI markers in extremely preterm infants (MRSI; SWI; PC-MRI; ihMT) to assess (1) if they can predict outcome until 2 years of age; (2) if they are of added value to 3 Tesla prematurity (Kidokoro et al., 2013) and (3) if…

EIS-GO: Early Identification of Steroid non-response in moderate severe active Graves* Orbitopathy,
a prospective study

To determine the accuracy of predicting steroid responders and non-responders with a whole blood in vitro steroid sensitivity assay.

Towards novel BIOmarkers to diagnose SEPsis on the emergency room

Objectives: 1) To compare the immune response of patients with or without sepsis presenting to the ED with a(n) (suspected) infection.2) To determine immune response aberrations that are associated with an increased risk of developing sepsis in…

Sensorimotor adaptation and learning in the control of human standing balance in cerebellar ataxia patients

The primary objective of this study is to establish whether cerebellar patient populations can adapt and learn to maintain standing balance when sensory-motor relationships of balance are modified. By comparing patient behavior with age-matched…

An Open-Label Extension Study of AKCEA-APOCIII-LRX Administered Subcutaneously to Patients with Familial Chylomicronemia Syndrome (FCS)

This study has been transitioned to CTIS with ID 2023-509029-29-00 check the CTIS register for the current data. In this study, we look at how safe the new medicinal product ISIS 678354 is for the treatment of FCS. And how well it works.

Glycocalyx restoration in chronic heart failure: a proof of concept, randomized, double-blind,
placebo-controlled study

To assess the efficacy of treatment with Endocalyx for chronic heart failure.

Protein synthesis rates in muscle tissue in vivo in patients with mitochondrial myopathy after high intensity interval exercise training

To assess the effect of unilateral high intensity exercise training on in vivo protein synthesis rates of vastus lateralis muscle in patients with mitochondrial myopathy.

An Open-Label Study of CK-3773274 for Patients with Symptomatic Hypertrophic Cardiomyopathy (HCM).

This study has been transitioned to CTIS with ID 2023-508963-58-00 check the CTIS register for the current data. Primary: To determine the safety and tolerability of CK­3773274 in patients with symptomatic HCMSecondary: Assess long-term effects of…

A Study of the Prevalence of Apolipoprotein L1(APOL1) Alleles Among Individuals With Proteinuric Kidney Disease Who Are of Recent African Ancestry or Geographic Origin

• Estimate the prevalence of APOL1 genotypes among individuals with FSGS who identify themselves as being of recent African ancestry or geographic origin• Estimate the prevalence of APOL1 genotypes among individuals with other forms of proteinuric…

Task-induced sensitized brain circuits during rTMS in major depressive disorder

The objective of this study is to detect whether stimulation during task induced activation of brainnetworks leads to a higher efficacy of rTMS and other neurobiological changes.

The impact of passive heat treatment on glycaemic response during an oral glucose tolerance test in diabetic patients

To assess the acute impact of passive heat treatment on the post-prandial glycaemic response during an OGTT in T2DM patients.

Evaluation of adhesions formation using conventional third generation endometrial ablation with and without postoperative application of an intrauterine adhesion barrier film

Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier

A randomized, double-blind, phase III study comparing NIS793 in combination with gemcitabine and nab-paclitaxel versus placebo combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)

The purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line mPDAC.This study aims to explore whether blockade of Transforming…

*A Positive Psychology Intervention for Cardiovascular Patients: a Single Case Experimental Design*

To examine whether the Positive Psychology group intervention *Goed leven met een hartaandoening* [Living well with heart disorder] is effective in increasing mental well-being, ability to adapt, positive skills (e.g. savouring, positive re-…