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Interoceptive abilities in adolescents with anorexia nervosa

Objective: The primary objective of this study is to investigate interoceptive abilities in adolescents with AN. To capture the multidimensional perspective, interoceptive abilities will be studied on an accuracy, sensibility and awareness level.…

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F (RUSH1F)

1. To report the natural history of retinal degenaration in patients with biallelic mutations in the PCDH15 gene.2. To identify sensitive structural and functional outcome measures to use for future multicenter clinical trials in PCDH15-related…

Hemodynamic characterization in hypertrophic cardiomyopathy after septal myectomy +/- mitral valve repair: a 4D-flow MRI study

Although this procedure has been performed for more than 20 years and clinical results after myectomy combined with AMVLE are satisfactory, very little is known about the effect of surgical myectomy intervention on the blood flow through the aortic…

An exploratory matched case-control study to measure blood nutrient levels of adult PKU patients on a protein substitute.

The study*s main objective is to measure blood micro- and macronutrient and amino acid levels in adults with PKU on a protein substitute and compare with age- and sex-matched non-PKU comparison subjects.

Decline in renal concentration ability in lithium treated patients

- to explore the decline in renal concentration ability (RCA) in a Dutch population of lithium treated patient - to explore the decline in kidney function

Optimizing INITIation of non invasive ventilation in ALS patients

The primary objective of this study is to build a predictive model in which we can identify which (pheno) type of ALS patients has the most benefit from NIV in improving or maintaining quality of life.

Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment

Primary objective:• To demonstrate that the DTAS triage workflow involving CBCT results in superior patient outcome in ischemic stroke patients with confirmed Large Vessel Occlusion (LVO) as compared to the conventional CT/MR triage workflow.…

Distribution, dosimetry and imaging of [195mPt]cisplatin in cancer patients

Investigate the distribution, dosimetry and image quality of [195mPt]cisplatin in cancer patients

RESET-TRD; a Randomised trial on oral ESketamine compared to Electroconvulsive Therapy for patients with Treatment Resistant Depression

This study has been transitioned to CTIS with ID 2024-517485-42-00 check the CTIS register for the current data. To investigate whether oral esketamine is non-inferior to ECT in achieving treatment response on depression severity in NTRD.

A40 EFL Registry: A Multicenter Prospective Study to Determine the Role of EFL in Patients with Chronic Obstructive Pulmonary Disease (COPD) Receiving Home Mechanical Ventilation
Protocol ID: SRC_HRC_VectorEURegistry_2019_10820

a. To determine what proportion of COPD patients demonstrate EFL during NIV useb. To determine the range of EPAP necessary to overcome EFLc. To determine longitudinal change of EFL with time and interaction with exacerbationd. To describe the…

A phase I/IIa open label study to assess the safety, tolerability, immunogenicity and clinical activity of EI-201 mRNA immunotherapy given intravenously in subjects with recurrent or metastatic HPV16 positive carcinoma

COHORT 1Primary objective: • To assess the safety and tolerability of IV administration of EI 201 as monotherapy in subjects with incurable R/M HPV16+ oropharyngeal and anogenital tumors and to select a starting dose of EI-201 for Cohort 2 Secondary…

Cardiac metabolic profiling in the fed state

The primary aim of this study is to provide insight into cardiac substrate utilization in the fed state.

A Prospective Randomized Multicenter Single Blinded Study to Assess the Safety and Effectiveness of the SELUTION SLR* 014 Drug Eluting Balloon in the Treatment of Below-the-Knee (BTK) Atherosclerotic Disease in Patients with Chronic Limb Threatening Ischemia (CLTI)

To demonstrate superior efficacy and non-inferior safety of the SELUTION SLR 014 DEB compared to PTA (uncoated balloon) in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.

An open-label, non-randomized extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan (LNP023) in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis

This study has been transitioned to CTIS with ID 2023-509343-27-00 check the CTIS register for the current data. Participants enrolling from study CLNP023B12301 or CLNP023B12302• Primary Objective: To evaluate the long-term safety and tolerability…

Longer-term effects of peanut consumption on brain function in older men and women.

The primary objectives are to investigate in older men and women the effect of 16-week peanut consumption on brain vascular function and brain insulin-sensitivity in cognitive-control brain areas, while we will also focus on changes in cognitive…

A PHASE Ia/Ib, OPEN LABEL, MULTICENTER, DOSE-ESCALATION STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND ACTIVITY OF RO7502175 AS A SINGLE AGENT AND IN COMBINATION WITH ATEZOLIZUMAB IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS

This study has been transitioned to CTIS with ID 2023-504709-35-00 check the CTIS register for the current data. This is a first-in-human Phase Ia/Ib, open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability,…

A Phase 1/2 Randomized, Blinded, Dose-escalation Study to Evaluate the Safety and Efficacy of Intrathecal Administration of AAV9-ABCD1 Gene Therapy (SBT101) in Adult Patients with Adrenomyeloneuropathy

This study has been transitioned to CTIS with ID 2024-518451-39-00 check the CTIS register for the current data. • To characterize the safety and tolerability of one-time IT administered SBT101 in adults diagnosed with AMN.• To characterize the…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Multicenter Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 Deficiency Disorder Followed by an Open-Label Extension

This study has been transitioned to CTIS with ID 2023-506269-78-00 check the CTIS register for the current data. Objectives for Part 1: Primary (Efficacy): To demonstrate that the efficacy of fenfluramine (ZX008) 0.8 mg/kg/day is superior to placebo…

A Phase 3 Randomized Study Comparing Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible

This study has been transitioned to CTIS with ID 2023-507632-20-00 check the CTIS register for the current data. The primary objective is to compare the efficacy of DVRd followed by cilta-cel and lenalidomide therapy versus DVRd followed by ASCT,…

A phase 3 randomized, double-blind study of ianalumab (VAY736) versus placebo in addition to eltrombopag in patients with primary immune thrombocytopenia (ITP) who had an insufficient response or relapsed after first line steroid treatment (VAYHIT2)

This study has been transitioned to CTIS with ID 2024-512890-28-00 check the CTIS register for the current data. The purpose of this study is to assess the efficacy and safety of ianalumab (VAY736) compared to placebo in addition to second-line…