12 results
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
To perform a comprehensive analysis of the cellular infiltrate in lesional AD skin, using state of the art immunohistochemical techniques.
The primary objectives are: 1. To assess BBB integrity in MPS IIIB patients by estimating the CSF AI.2. To determine the BBB transfer coefficient by DCE-MRI in MPS IIIB patients.The secondary objectives are: 1. To describe the relationship between…
The primary aim of this project is to define the role exacerbations play in the pathophysiology of COPD. Moreover, the study has the aim to determine the long-term effects of PR and the natural course of the disease. The unique design of MCC will…
Analyze processes related to DNA-damage in oocyte development and early-developmental stage embryos from BRCA1/2-mutation carriers compared to controls, using immunohistochemistry and RNA-Seq technology.
1. To assess whether microarchitectural alterations in the brain of different types of craniosynostosis patients are indeed primary.2. To assess local cerebral perfusion in craniosynostosis patients and its change after surgery.3. To understand the…
- The primary research objective is to estimate the prognosis of children affected by ICL. - A secondary research objective is to explore the heredity of ICL between first degree family members.
As none of the proposed experimental conditions have been executed with chronic pain patients, our main objective is to determine the sensitivity of the experimental conditions. Besides, we investigate the attention-bias for pain signals that…
The objective is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents.
The end-points of this study are:1. To evaluate the prevalence of dRTA in Sjögren using a new screening test with furosemide and fludrocortisone and compare this against the gold standard test with ammonium chloride2. To determine the prevalence of…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in schizophrenia. Since cognitive dysfunction is the most disabling and untreatable characteristic of…
To suppress low-level viremia to a level below 50cp/mL in patients using cART by switching their current non-nucleoside reverse transcriptase inhibitor (NNRTI) or PI to DRV boosted with ritonavir (RTV) (DRV/r). Secondary objectives are to reduce the…