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IMPROVED: Induction therapy with Methotrexate and Prednisone in Rheumatoid Or Very Early arthritic Disease;A randomized clinical trial in patients with recent-onset arthritis to compare the efficacy of DMARD combination therapy including prednisone with combination therapy including adalimumab, a TNF-blocking agent.

The objectives of this study are:* To determine the percentage of patients with recent-onset RA and UA who achieve and maintain clinical remission on treatment with a combination of methotrexate 25 mg/week and extended prednisone pulse (tapered high…

PITUITARY DAMAGE AFTER TRAUMATIC BRAIN INJURY;
Occurrence of growth hormone deficiency at long term follow-up and the beneficial effects of growth hormone substitution on cardiovascular performance, quality of life and functional abilities

To evaluate whether GH substitution in patients with an isolated GHD after TBI could reverse the severity of symptoms which characterize GHD.

The effect of nebulised MgSO4 on lung function in stable severe asthma patients with persistent airflow limitation

To test this hypothesis by administering inhaled isotonic magnesium sulphate to patients with stable severe asthma and persistent airflow obstruction (postbronchodilator FEV1 < 75% predicted) and determine the bronchodilating effect by…

A randomized, double blind, parallel group study of vardenafil flexible dose versus placebo in males with erectile dysfunction and their female partners* sexual quality of life. PARTNER II.

1. Success of maintenance of erection in men with ED.and 2. Improvement of their female partner*s sexual quality of life.

Cryoplasty of the femoropopliteal arteries in patients with intermittent claudication compared with conventional angioplasty: a randomized study

Our aim is to evaluate the patency of cryoplasty in patients with intermittent claudication or critical ischemia, where exercise training is ineffective. Furthermore, we will evaluate whether cryoplasty will significantly improve the quality of life…

Drug interactions between ATOvaquone used in MAlaria prophylaxis and antiretroviral agents in HIV-1 infected patients (ATOMA)

To determine the effect of antiretroviral agents (low-dose ritonavir + lopinavir, low-dose ritonavir + atazanavir, efavirenz) on the pharmacokinetics of single-dose atovaquone determined by intersubject comparison. Secondary objectives: - to…

A randomised blinded comparison of surgical intervention with the X STOPPK® interspinous process decompression versus surgical decompression for patients with intermittent neurogenic claudication caused by lumbar stenosis

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with X STOPPK is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

Long-term functional outcomes of extraarticular distal radius osteotomy for the treatment of extraarticular distal radius malunion

The aim of this project is to do an objective and subjective functional long-term outcome assessment of patients with distal radius malunions, treated with intraarticular osteotomy and therefore evaluate factors that are good outcome predictors for…

CHRONIC PAIN MANAGEMENT AFTER HERNIORRAPHY
PREGABALIN VERSUS PLACEBO

The primary objective of this study is to investigate whether pregabalin at a dose of 150-600 mg twice a day reduces pain in patients with chronic neuropathic pain after herniorraphy. This research question will be answered by testing of the…

pharmacokinetics and toxicity of linezolid in MDR-TB patients

To study the pharmacokinetics of linezolid in MDR-TB patients, specifically in the relationship to dose, treatment duration and toxicity.

Dexamethason for the treatment of exacerbations in multiple sclerosis

In this double-blind randomized controlled trial, we would like to show that a five-day treatment course with 16mg/day oral dexamethason is effective in inducing recovery from an exacerbation of MS. The advantages of oral dexamethason over…

Pharmacogenetics and epilepsy; analyse van de respons op lamotrigine

To evelauate whether the presence of selected polymorphisms has an effect on the response to lamotrigine.

The METEX Study: methotrexate versus expectant management in women with ectopic pregnancy

To study whether in women with EP with low but plateauing serum hCG concentrations treatment with systemic methotrexate in a single dose intramuscular regimen is superior over expectant management in terms of treatment success, future pregnancy,…

A twelve-month, multicenter, open-label, randomized study of the safety, tolerability and efficacy of Certican* with Simulect, corticosteroids and two different exposure levels of tacrolimus in de novo renal transplant recipients

With the goal of improving kidney function and without causing an increased number of rejections, is it possible to reduce tacrolimus dosage through the use of the previously-mentioned immunosupressives after month three.

Levobupivacaine for pediatric caudal block. Comparison of three different dose in children undergoing hypospadia repair: a double-blinded randomised study

To determine the best doses-respons of levobupivacaine for postoperatief analgesia after caudal anesthesia for hypospadia repair.

The effect of the short-term combined use of NSAIDs and diuretics/RAAS-inhibitors on the heart- and kidneyfunction in orthopaedic patiënts.

1. IS there an effect of short-time combined use of NSAIDs and diuretics/RAAS-inhibitors on the heart- and kidneyfunction in orthopaedic patiënts who undergo a total knee- or hipreplacement.2. Is cystatin C a better endogenous marker of kidney…

Endometrial Tissue Ablation, a clinical trial.
Hydrotherm vs. Novasure

Demonstrate that HydroThermAblation is equally effective compared to Novasure in improving quality of life, satisfaction, amenorrhoea and complications.

Comparison of the fixation and stability of two bone substitutes: Pro Osteon and Calcibon by revision of the acetabulum prosthesis with RSA

Which of the products, Pro Osteon or Calcibon gives the best stability and fixation of the acetabulum prosthesis by revision procedures.

"Is a simultaneaus intervention of triamcinolon injections with standardized isometric exercises more effective compared to the usual care according to the NHG standard in patients with shoulder complaints.
A prospective, singel blind, randomized clinical trial."

Therefore the aim of the present study is wheter a simultaneus intervention witht (maximal 5) corticosteroïden/lidocaine injections and exercises for the cuff muscles (both according a standard protocol), have better results than a sequential…

Is premorbid functioning a predictor of outcome in patients with early onset psychosis treated with Risperdal Consta?

The objective of this study is to investigate whether patients with a good premorbid functioning have a beter treatment response after treatment with Risperdal® Consta® than those patients with poor premorbid functioning. Premorbid functioning of…