888 results
Subgroup 1 (complex appendicitis without mass and/or abscess formation): LA is associated with reduced superficial site infections, shorter length of stay, less costs, less pain, and better hr-QoL, compared with OA without compromising overall…
The primary objective of this study is to determine patient perspective of and satisfaction with follow-up type and frequency after THA and TKA. Therefore, we will send surveys to patients who had a THA or TKA between 1 and 15 years ago.
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
- Six weeks of ESM combined with personalized feedback sessions, compared with treatment as usual (TAU), leads to a stronger reduction in fatigue symptoms (primary outcome clinical effectiveness). - This intervention also leads to improvements in…
The primary goal of this study is to compare ultrasound-guided ANB with FHB for analgesia during closed reposition of distal forearm fractures. Secondary goals are evaluation of feasibility in the ED regarding time and procedure success rate.…
• To demonstrate the efficacy of ATR-002 versus placebo in addition to standard of care based on the clinical severity status in adult hospitalized patients with COVID-19• To show that ATR-002 in addition to standard of care shortens the time to…
The main objective of the study is to assess the albuminuria lowering effects of semaglutide 2.4 mg s.c. once weekly (Semaglutide 3 mg/ml) compared to placebo in obese/overweight non-diabetic individuals with elevated albuminuria.
The objective of this Phase 3 study is to investigate the safety and efficacy of benralizumab as a treatment for patients with eosinophilic gastritis and/or gastro-enteritis.
The objective of this study is to assess the feasibility of SCS using the Wavewriter Alpha for control of treatment resistant endometriosis-related pain symptoms
Assessment of the Axone micro quadripolar electrode for enhanced cardiac resynchronization therapy.A clinical study designed to obain the CE-mark.This new, quadripolar micro electrode allows for easier placement of the left ventricular lead,…
Study of a novel implantable device to generate an autologous vascular graft for hemodialysis access
The objective of the study is to assess the use of the Tissue Capsule for AV grafting in renal failure patients and testing these AV grafts for hemodialysis access.
The main objective of the current project is to assess the effect of jumping exercise combined with collagen supplementation on bone turnover. This will be investigated by means of two sub-studies.Sub-study 1a: To examine the effect of collagen…
The objective of this study is to assess the added value of polygenic risk scoring in psychiatric genetic counseling for patients with serious mental illness (SMI) and their family members. The secondary objective of this study is to explore…
Primary, Part A: - To assess the effect of SAR443820 compared to placebo in reducing ALS progression as measured by the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R)Primary, Part B: - To assess the long-term effects of…
Primary• To evaluate the safety and tolerability of single ascending IV doses of ANX105 in normal healthy participantsSecondary• To characterize the single-dose PD of ANX105• To characterize the single-dose PK of ANX105
This study has been transitioned to CTIS with ID 2023-505023-31-00 check the CTIS register for the current data. 1) To compare disease-free survival (DFS) as assessed by investigator for participants treated with belzutifan plus pembrolizumab versus…
The primary objective of the trial is to assess a non-flat dose-response curve and to evaluate the dose-response relationship for 3 oral dose regimens of BI 1291583 versus placebo, on the primary endpoint, time to first pulmonary exacerbation up to…
The primary objective of this study is to evaluate the safety and tolerability of iscalimab at two dose levels (600 mg and 300 mg) in patients withSjögren*s Syndrome, who participated in the TWINSS core study,CCFZ533B2201.Secondary…
PrimaryTo assess the efficacy of ravulizumab in the treatment of participants with TMASecondaryTo characterize TMA responseTo assess impact on hemoglobin levels To evaluate change in kidney function To assess duration of Complete TMA Response and…
Primary Objectives:Our primary objectives are:1. To evaluate the safety, tolerability and pharmacokinetics of intravenously (IV) administered M6229 in critically ill patients with sepsis with specific attention to anti-coagulation effects (based on…