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A pilot feasibility study of Dose dE-eScalaTion IN prostATe radIOtherapy with empty bladder usiNg the
MRL - DESTINATION 1B(ladder)

To develop a 5 fraction de-escalated dose SBRT protocol potentially capable of reducing side effects intended for prostate cancer patients with empty bladder

Implementation of a home-based computerized cognitive rehabilitation program for patients with acquired brain injury

Patients with ABI follow a multidisciplinary rehabilitation program. This program is very intensive and also requires a lot from loved ones. The burden can be reduced by partly delivering the program from home.The aim of this project is to implement…

The DRAGON-PLC trial: An international multicentre randomised controlled trial to compare combined Portal and Hepatic Vein Embolisation (PVE/HVE) with PVE alone in patients with primary liver cancers.

To evaluate the effect of combined PVE/HVE compared to PVE alone on resectability and overall survival in patients with primary liver cancers.

The influence of female sex hormones on the subjective and cognitive response to cannabis

Primary Objective: To assess the acute subjective drug effects (good/bad drug effect, drug liking/wanting, anxiety), cognition (attention, working memory, information processing speed, verbal memory, verbal fluency, motor inhibition), and…

HIPPI shoulder - Hip-allograft In Proximal humerus fractures versus Plate Implantation alone: a randomized controlled trial

The aim of this RCT is to examine the differences in functional, clinical, and radiological out-comes, between LCP fixation alone and femoral allograft augmentation in addition to LCP. Ultimately, the purpose is to optimize treatment strategies and…

Intradialytic monitoring of mitochondrial oxygen tension and bioimpedance.

The general aim of the current project is to assess the feasibility of two novel monitoring techniques, intradialytic mitoPO2 monitoring and continuous bioimpedance and assess the impact of hemodialysis on mitochondrial level by studying the change…

FAFOR

Primary Objective: to determine the dose effect relationship between radiation dose and liver function by comparing the change in liver function after SBRT in whole liver and liver sub-volumes receiving a low/medium/high doses of radiation.

ExerciseEnhances+: A prospective cohort study on the synchronization of exercise therapy and cognitive behavioural therapy in depression

This study will assess the effect of combining exercise therapy with CBT 12-16 weeks and explore the mechanisms underlying exercise*s mood- and plasticity-boosting effects. The primary question is whether a higher dose of exercise leads to faster or…

Optimization of parameters of automatic Fraction of Inspired Oxygen (FiO2) control for use with preterm patients

Find the best method, with the lowest area outside of the patients SpO2 target range, for oxygen control in premature neonates.

The microcirculation, dialysis modality and sequestered salt (the MIMOSA study)

Four hypotheses will be investigated. First and second, we will evaluate whether treatment with hvHDF has dissimilar effects on the SSC and MC function, if compared to HD. Next, we will assess whether disorders of the SSC and the MC are influenced…

Effects of PERMISSive Lung–protective Ventilation in Critically Ill Invasively Ventilated Patients (PERMISS)

To study the feasibility and safety of permissive lung–protective ventilation in adult critically ill patients receiving invasive ventilation for acute hypoxemic respiratory failure, and to inform the design of a future randomized clinical trial in…

Safety and feasibility of CT-guided percutaneous radionuclide therapy with the OncoSil* device in patients with non-progressive locally advanced pancreatic cancer (PANCOSIL): an open-label, single-arm phase 1-2 feasibility study

To assess the safety and feasibility of percutaneous CT-or ultrasound-guided RNT using the Oncosil* device in patients with non-progressive LAPC after induction chemotherapy treatment.

Differences between EMG-MT, OM-MT, and NCG as methods to establish the cortical threshold in TMS.

The study will consist of two components. In the first component, OM-MT and EMG-MT will be observed within subjects, with counterbalancing applied to prevent order effects. Pain will be measured by applying a small portion of the FDA-approved 10Hz…

Effect of inulin supplementation on glycaemic control and immunological parameters in type 1 diabetes

To establish the effect of oral inulin supplementation on continuous glucose monitoring (CGM) metrics and immunological parameters in adults with type 1 diabetes.

Desynchronization of neural activity by weak electric fields

This study aims to test if weak electric fields, as they occur during tACS, desynchronize somatosensory evoked potentials. Further, if they can, it aims to quantify at which tACS amplitude the desynchronization occurs.

Clinical proof-of-concept of millisecond dose delivery potential in moving targets.

The primary objective is to investigate the targetability of a moving lung tumor with proton therapy, to provide a proof-of-concept for the potential of millisecond dose delivery in lung cancer patients.

The added value of a behavioural weight reduction program to blended rehabilitation in patients with chronic low back pain: A randomized clinical trial

The primary scientific objective of this multicenter study is to examine if adding a behavioral weight reduction program to pain neuroscience education and cognition-targeted exercise therapy, compared to pain neuroscience education and cognition-…

The effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill patients.

The primary objective of the CONVEnIENT trial is to investigate the effect of daytime intermittent enteral tube feeding, compared to a standard continuous tube feeding pattern (24-hour/day), on glycaemic control, gastrointestinal function, circadian…

Optically Pumped Magnetometers to characterize neurophysiological correlates of psychiatric treatment effects

The main goal is to demonstrate that OPM-MEG can be used successfully in patients with psychiatric disorders, by allowing subjects to move whilst recording magnetic electrophysiological activity, and has potential as a novel diagnostic method in…

A Prospective, Multicenter, Randomized Clinical Investigation Evaluating the Safety and Efficacy of ETHIZIA* versus SURGICEL® Original in Controlling Minimal, Mild, or Moderate Soft Tissue Bleeding During Open Abdominal, Retroperitoneal, Pelvic, Thoracic (Non-cardiac), and Extremity Surgery

The randomised safety and efficacy assessments of ETHIZIA are currently being evaluated in ongoing IDE trials where ETHIZIA is compared to TachoSil and SURGICEL® Original during open and minimally invasive liver surgery, respectively. This soft…