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A 24-week, multicenter, international, randomized (1:1), parallel-group, open-label, comparative study of insulin glargine versus liraglutide in insulin-naïve patients with Type 2 diabetes treated with oral agents and not adequately controlled, followed by a 24-week extension period with insulin glargine for patients not adequately controlled with liraglutide

The primary objective of this study is to demonstrate the superiority of insulin glargine over liraglutide in termsof percentage of patients reaching a HbA1c < 7% at the end of the comparative period in Type 2 diabetic patientsfailing…

A prospective patient registry for bonegraft substitutes in spinal fusion

To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.

Genetic Susceptibility to Papilloma-induced Voice Disturbance

To discover human genes which are likely to confer susceptibility for recurrent respiratory papillomatosis

Effect of biphosphonates on teleangiectasia in irradiated breast cancer patients

To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.

The Role of the Intestinal Barrier Function in Liver Cirrhosis

Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…

Brown Adipose Tissue Activity in Caucasians and South Asians

Main objective: 1) To investigate whether BAT activity differs between South Asians and Caucasians.Secondary objectives: 1) To investigate whether sympatic stimulation of BAT differs between South Asians and Caucasians2) To investigate the…

A multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, preliminary clinical activity and immunogenicity of multiple doses of MOR103 administered intravenously to patients with active rheumatoid arthritis.

Primary objective:To determine the safety and tolerability of multiple doses of MOR103 in patients with active rheumatoid arthritis, at ascending dose levels.Secondary objectives:- to evaluate signs of efficacy of MOR103 in patients with active…

The role of corticosteroids on coagulation and inflammation in asthma

Primary objective:- To evaluate the effects of a 10 day-course of prednisolon on coagulation and fibrinolysis parameters in patients with mild-moderate astma, patients with severe asthma, and healthy controls.Secondary objectives:- To compare the…

Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia

W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia

A novel neurophysiological measurement (MUNIX) in neuromuscular disorders; test-retest reliability and longitudinal follow up measurements in ALS patients

PrimaryTo investigate the inter-rater and intra-rater variability of a novel neurophysiological measurement (Motor Unit Number Index, MUNIX) for estimation of functioning motor units, in healthy controls and ALS patientsSecondaryTo evaluate the…

Effects of Human Unacylated Ghrelin on Insulin Sensitivity during Euglycemic-Hyperinsulinemic- Clamp in Patients with Type 2 Diabetes Mellitus

One of the he questions that remains to be answered to further elucidate the mechanism of action is whether ot not UAG improves insulin sensitivity during a euglycemis-hyperinsulinemic clampThis study aims to clarify the effects of the continuous…

An open-label phase 2A study to investigate drug-drug interactions between AT1001 (migalastat hydrochloride) and agalsidase in subjects with Fabry disease.

The primary objectives of this study are: * To characterize the effects of 150 mg and 450 mg of AT1001 administered 2 hours before administration of agalsidase on the safety and plasma pharmacokinetics of agalsidase in subjects with Fabry Disease*…

Skeletal muscle characterization in frail elderly

To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.

A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Determine
the Efficacy, Safety, and Tolerability of AMG 785 in Adults with Fresh Unilateral
Hip Fracture, Status Post Surgical Fixation

To investigate the effect of AMG 785 compared to placebo on functionalhealing as measured by the timed-up-and-go test (TUG) over Weeks 6 through 20 in subjectswith fresh unilateral low energetic hip (intertrochanteric or femoral neck) fracture

Topical Vitamin D3, Diclofenac or a combination of both to treat Basal Cell Carcinoma

Primary Objective: To determine whether topical application of Calcitriol (Silkis) 3 µg/g, Diclofenac 10% or a combination of both can lead to a 40% histological reduction (*)/increase (*) of expression of the following antibodies: Ki67 (*), BCL2…

Study of the effectiveness of a coping self-help intervention for women in the waiting period after an embryo transfer during an IVF/ICSI treatment

To investigate if a short copingintervention reduces anxiety in patients undergoing an IVF or ICSI treatment in the UMCU during the waitingperiod after an embryotransfer.

INTERVENTIONAL MANAGEMENT OF STROKE TRIAL CLINICAL PROTOCOL - IMS III
A phase III, randomized, multi-center, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (Activase®/Actilyse®) alone when initiated within three hours of acute ischemic stroke onset.

The primary objective of the trial is to determine if ischemic stroke subjects with a baseline NIH Stroke Scale Score (NIHSSS] >= 10 (8-9 with positive CTA) treated with recombinant tissue plasminogen activator (rt-PA; [Alteplase recombinant…

Evaluation of the effectiveness, safety, and tolerability of tapentadol PR versus a combination of tapentadol PR and pregabalin in subjects with severe chronic low back pain with a neuropathic pain component

Primary objectiveThe primary objective is to evaluate the effectiveness, safety, and tolerability of increasing doses of tapentadol PR (300 mg per day after run in, up titration to 500 mg per day) versus a combination of tapentadol PR (300 mg per…

Long term prospective observational cohort study of the safety and efficacy of golimumab in the daily clinical practice of rheumatoid arthritis with emphasis on the lipid profile

To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.

A Phase IIIb Double-Blind, Randomised, Placebo-Controlled Study of Patient Reported Outcomes in Friedreichâ¤*s Ataxia Patients after withdrawal from Treatment with Idebenone (PROTI Study)

The primary objective of the PROTI study is to establish whether patients can correctly determine which treatment assignment they received during the randomised phase of the trial.The key secondary objective is to compare the rate of withdrawal from…