30 results
The aim of this study is to explore the incidence of MTX related gastro-intestinal in a large cohort of JIA patients. Secondly, we want to investigate the effect of psychological behavioural therapy or switch to parenteral MTX dosing to ameliorate…
The purpose of this study is to determine the effects of a strength training program on physical functioning in children with CP.
The main parameter of the study is evaluation and effectiveness of the treatment program on Body Mass Index (BMI) (as defined by Cole et al) compared to a standard intervention (increased physical activity and nutrient advice). Also the…
Dividing the study population in four categories (oncological patients, critically ill patients admitted to intensive care, neonates and other children) answers to the following questions are sought:- which initial dosage regimen for vancomycin…
The aim of this study is determine the efficacy and safety of Metformin as a weight reducing drug in the euglykemic, obese paediatric population.
The primary objective is to determine the pharmacokinetic characteristics of galantamine after 2 single oral doses in children with Down syndrome. Secondary objectives are to evaluate safety and tolerability.
Purpose: is there a rotational disability after Prevotnailing of forearm fractures in children and is this caused by a bony deficit.
Primary Objective: To investigate the effect of treatment with nebulized rhDNase targeted to the peripheral airways compared to rhDNase targeted to the central airways on FEF75 in children with CF who are on maintenance treatment with rhDNase.…
The purpose of this study is to improve, implement and evaluate an intervention program to improve physical activity in daily life and sportsparticipation of adolescents and young adults with MMC. The purpose of the intervention "Active…
To determine the feasibility of a trainingprogram in childhood cancer survivors in the primary health care system
The objective of this extension study is to assess the long-term safety and efficacy of Myozyme treatment in patients with Late-Onset Pompe Disease who were previously treated under the placebo-controlled, double-blind study AGLU02704.
To develop valid and reproducible protocols to measure cardiorespiratory fitness (VO2peak and energy cost of locomotion) in ambulatory children with SB. These protocols will allow further studies regarding physical fitness in these children.
We hypothesize that NK and/or T cell-mediated immunotherapy may represent a novel therapeutic option for patients with refractory and/or metastatic ES. Therefore, we will study molecular mechanisms that determine the susceptibility of ES to T and NK…
To evaluate the two procedures for lengthening of the mandible.
Primary Objective:To evaluate the efficacy of Oxabact TM to reduce urinary oxalate levels from Baseline to Week 24 in subjects with Primary Hyperoxaluria (PH).Secondary Objectives:To evaluate:* Percentage of subjects who have 20% or greater…
To study the effects and costs of the total individual CBT package and one of the components of the total CBT treatment package (i.e. mindfulness training) in a group format compared to Treatment-as-Usual (TAU) on the short and long term.
The primary objective is (1) to establish the feasibility of using these neurocognitive tasks in children, and (2) to establish intra-individual variance of task results upon test repetition.The secondary objective is to assess how children have…
This current study aims to investigate the use of bèta-TCP, a synthetic tricalcium phosphate, as a filler of the autologous symphyseal bone graft harvest site in patients undergoing grafting of clefts of lip, alveolus and palate.The specific…
binaural hearing in children and teenagers with a severe hearing loss with bilateral hearing devices
determine the effect of a HA in combination with a CI in children as well asdetermine the effect of bilateral cochlear implantation.
To characterize the multiple-dose pharmacokinetics of varenicline in adolescent maleand female smoking subjects