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Cognitive behavioral therapy (CBT) and physical exercise for climacteric symptoms in breast cancer patients experiencing treatment-induced menopause.

The proposed study will evaluate the efficacy of a supportive intervention program in alleviating menopausal symptoms, improving sexual functioning and enhancing the quality of life of younger women (< 50 years) with breast cancer who have…

An open label, randomised, muliticentre Phase III Trial of Dasatnib (SPRYCEL®) vs standard dose Imatininb (400mg) in the treatment of subjects with newly diagnosed chronic phase Philadelphia chromosome positive chronic myeloid leukaemia (CML).

To compare the best confirmed complete cytogenetic response (CCyR) rates within 12 months in newly diagnosed chronic phase CML subjects treated with dasatinib versus imatinib

Effects of left ventricular pacing optimalisation on cardiac perfusion, contractile force, and clinical performance in patients with ventricular dysfunction and heart failure

To compare a surgical approach with the conventional transvenous approach by assessment of differences on the effects on cardiac perfusion and relate this to the clinical cardiac function.

An Exploratory, Multi-center, Open-Label, Single-Arm study to evaluate the Discontinuation Effect of Clopidogrel After Drug Eluting Stent (DECADES) on
Inflammatory and Platelet Activation Markers in Subjects Who Are Receiving Low Dose Acetylsalicylic Acid (ASA)

Primary Objective: To assess whether the withdrawal of clopidogrel 12 months after Drug Eluting Stent (DES) implantation leads to an increase in markers of inflammation and platelet activation.Secondary Objectives: To assess the withdrawal of…

A Randomized, Double-blind, Multicenter, Phase 2 Study of a Human Monoclonal Antibody to Human aV Integrins (CNTO 95) in Combination With Docetaxel and Prednisone for the First-Line Treatment of Subjects With Metastatic Hormone Refractory prostate Cancer

Evaluate the efficacy and safety of treatment with CNTO 95 in combination with docetaxel and prednisone compared with docetaxel and prednisone without CNTO 95 in subjects with metastatic HRPC.

A Multicenter, Open-Label Study of doxercalciferol capsules for the Treatment of Secondary Hyperparathyroidisms (SHPT) in Stage 3 or Stage 4 Chronic kidney Disease (CKD) Patients

Primary Objective: To evaluate the safety and tolerability of Hectorol Capsules during 52 weeks of treatment in patients with Stage 3 or Stage 4 CKDSecondary Objective: To evaluate the efficacy of Hectorol Capsules during 52 weeks of treatment in…

Epidural analgesia versus Remifentanil PCA during labour

To compare Remifentanil PCA with epidural anesthesia among healthy nulligravidia during labor.

Chemotherapy Adjuvant Study for women at advanced Age (CASA); Phase III Trial Evaluating the Role of Adjuvant Pegylated Liposomal Doxorubicin (PLD, Caelyx®, Doxil®) for Women (age 66 years or older) with Endocrine Nonresponsive Breast Cancer Who Are NOT Suitable for Being Offered a *Standard Chemotherapy Regimen*

The overall aim of the CASA trial is to investigate the role of PLD as adjuvantchemotherapy for older postmenopausal women for whom chemotherapy is indicated, but standard regimens, derived from trials in younger women, are assumed to be too toxic…

AMPUTATION, THROMBOSIS AND PULMONARY EMBOLISM

De intentie van deze studie is het objectief vaststellen van de incidentie van veneuze trombo-embolische complicaties bij patiënten die een amputatie van het been ondergaan middels uitgebreide duplex-echografie en longperfusie scan.

A Dutch Prospective, Multi-disciplinary, Multicentric And Randomized Study To Compare Minimally Invasive Reduction and Fixation Using The Kyphx-System And Radiopaque PMMA Cement To Non surgical Therapy Alone For The Treatment of Painful, Acute Osteopenic Vertebral Body Compression Fractures

The objective of this study is to compare the cost and effectiveness of standard non surgical management alone to balloon kyphoplasty using the KyphX-system for the treatment of acute vertebral body compression fractures.

Pharmacokinetics of levetiracetam after rectal administration in healthy volunteers

Comparison of single-dose pharmacokinetics of levetiracetam after rectal versus oral administration at healthy volunteers.

A double blind randomized study on the effectiveness of cyclopentolate 1% and cyclopentolate 1% with tropicamide 1% in dark irided hypermetropic children

To compare the effectiveness of 1) double dose of cyclopentolate and 2) one dose of cyclopentolate and one dose of tropicamide with 3 days, total 5 doses atropine.To investigate whether one dose of tropicamide combined with cyclopentolate is as…

A Prospective, Randomized, Placebo-Controlled Multicenter Study to Evaluate the Performance of the IBV Valve System for the Treatment of Severe Emphysema

The objective of this randomized, blinded, multicenter, controlled study is to compare the performance of the IBV* Valve System (treatment group) to a control group receiving a sham bronchoscopy procedure without valve placement

Farmacokinetics and farmacodynamics of drugs used in neonates and children during Extracorporal Membanous Oxygenation (ECMO)

The objective of the study is to karacterize Pharmacokinetics and pharmacodynamics of frequently and routinely used drugs in children and neonates undergoing ECMO treatment and ultimately to formulate dosing regimes for these drugs for patients…

Evaluating bone re-angulation after pediatric forearm fracture in the growing child

Regaining insight in the re-angulating capacity of angular deformities in forearm fractures of the juvenile bone. Thereby making use of radiologic, clinical and functional parameters.

Paclitaxel-eluting stent versus conventional stent in STE-myocardial infarction; angiographic long-term evaluation;Long-term angiographic follow-up after primary PCI for acute myocardial infarction; paclitaxel-eluting stent versus bare metal stent, as performed in the PASSION trial
A single blinded, randomized, dual center study

Angiographic follow-up of DES in large patient groups late after primary PCI is currently unavailable. By extending the PASSION protocol, we have the opportunity to have the first angiographic analysis two to four years after primary PCI, both after…

'The effects of Omega-3 Fatty Acids Dietary Supplements (Fish Oil) on Impulsivity in Patients with a Personality Disorder'

The primary research question of this study is:*What is the effect of omega-3 fatty acids dietary supplementation compared to placebo in the treatment of impulsivity in patients with a personality disorder?*The secondary research question of this…

The effects of an implantable FES device (Actigait) on walking skills in stroke patients with a drop foot

The main goal of this study is to evaluate the effectiveness of Actigait on walking skills in stroke patients with a drop foot.

Automatic Weaning Using Adaptive Support Ventilation (ASV) * Effect of an Early Weaning Protocol on Time till Extubation of Coronary Artery Bypass Surgery Patients

To determine whether ASV with a proactive approach results in shorter weaning time as compared to ASV alone.

A Phase I, open-label, randomized, 2-way crossover trial in 2 parallel panels of 20 healthy subjects each to investigate the pharmacokinetic interaction between lopinavir/ritonavir (LPV/rtv) and telaprevir, and between atazanavir/ritonavir (ATV/rtv) and telaprevir, all at steady-state.

The first aim of the study is to investigate the effect of telaprevir on the concentration of LPV/rtv and ATV/rtv in the blood and the effect of LPV/rtv and of ATV/rtv the concentration of telaprevir in the blood.The second aim is to investigate the…