2231 results
The primary goal of the current study is to study the safety of and serological response to the MMR booster vaccination in JIA patients. Based on a retrospective analysis we hypothesize that MMR vaccination does not aggravate JIA disease and that…
To identify complement donors with no or low antibodies to Meningococcal strains to be used used as a complement source in SBAs against a panel of meningococci during evaluation of clinical trial samples
Primary objective: The primary purpose of the study is to investigate the effect of the Heart Coach program (in addition to usual care) on the individual risk factors body mass index, waist circumference, blood pressure, cholesterol, physical…
To assess the costs and effects of tailoring the duration of elastic compression stocking (ECS) therapy after deep vein thrombosis (DVT) to individual patients needs.
* To demonstrate efficacy of the candidate vaccine in the prevention of (1) persistent infection (6-month definition) with HPV-16 or HPV-18 (by polymerase chain reaction [PCR]) and/or (2) histopathologically-confirmed CIN1+ associated with HPV-16 or…
1) Identify chemopreventive properties of mesalazine in patients at high risk of recurrent (nonfamilial) colorectal adenomas by evaluating the effect of treatment on apoptosis and proliferation in histologically normal sigmoid and rectal mucosa…
The objective of the study is to improve the peri-operative care for fragile older patients who have been indicated for elective surgery of thorax and abdomen.
The primary objective of the study is to relate depression and anxiety in CHF patients receiving an ICD to the occurrence of ventricular tachyarrhythmias. Secondary objectives of the study are:Assessment of the effects of depression and anxiety on…
Driven by the hypothesis that combination of dietary polyphenols, with distinct mechanisms of action, may improve cellular energy and fatty acid metabolism, preventing thereby the development of the metabolic syndrome and diabetes, the following…
Our objective is to assess whether patients with SM compared to controls have more advanced atherosclerosis assessed by carotid intima-media thickness (C-IMT) and carotid plaques and have a more adverse cardiovascular risk profile.
The current research proposal aims to investigate the medium and long-term health benefits of a combined supervised exercise and dietary intervention versus a dietary intervention (=usual care) in obese long-standing type 2 diabetes patients. It is…
This is a two part proof of efficacy study of KAF156 as a causal prophylactic agent in malaria. Results will be used to guide dose selection for further development of KAF156 in patients.
To protect children with hiv and children using immune-suppressive medication against hepatitis A and B, and to determine the immunogenicity of the combined hepatitis A and B vaccine in these children.
To examine whether heating can prevent the hyperglycaemia-induced decline in endothelial function in T2DM and age- and sex-matched controls.
To investigate what the ideal moment to vaccinate would be, early (after 2-6 months) or late (after 9-12 months) after cessation of rituximab. Secondly to study the immune-response to vaccination with influenza virus vaccine after treatment with…
The purpose of this clinical pilot study is to generate quantitative evidence that the oral administration of 80 mg Simvastatin per day, three weeks before surgery and one week thereafter, will have a significant effect on fibrinolytic activity…
Primary objective of the OPTICARE study is to evaluate whether patients with acute coronary syndrome (ACS) will derive additional benefit from an extended CR program compared to standard CR.
Measurement of the pain index, NoL, during laryngoscopy, intubation and skin incission during variations in de level of propofol and remifentanil.
Primary Objective: The primary goal is to evaluate the effectiveness of a prevention program for adolescents. These adolescents are children of parents who receive treatment at a mental health care institution for their internalizing problems (…
The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…